ArticleJournal of cosmetic dermatology2025
Liquid Polycaprolactone (PCL) for Reversing PXE's Skin Laxity of Inner Thighs and Knees: A Case Report.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Skin Quality and Safety Following Liquid-Form Polycaprolactone for Facial Rejuvenation: A Prospective Single-Arm Study.Dermatology and therapy · 2026Article
- Skin Wound Healing Following Injecting Hyaluronic Acid Rejuvenating Complex, Polycaprolactone, or Combination Therapy: An Experimental Study.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimPseudoxanthoma elasticum (PXE) is a genetic connective tissue disorder that affects the skin with limited treatment options. A recent technology employing particle-free polycaprolactone (PCL) has shown promising results in treating inner thighs and kness of a 27-year-old female patient. This article provides a case report along with our detailed treatment protocol based on the efficacy of PCL in reversing skin laxity that can be easily incorporated into the therapeutic approaches for patients with PXE.
methodsThe pinch test for clinical assessment, photographic documentation as well as satisfaction questionnaire were used in order to evaluate the improvement observed in skin laxity.
resultsAfter the finish of the protocol, the Pinch test score was diminished from 4 to 2, and the depth of the wrinkles was obviously improved in the photos. All the above, together with the high score of the patient satisfaction questionnaire, verified the efficacy of this novel PCL protocol in reversing PXE's skin laxity.
conclusionFully liquid PCL appears to outperform other bio-stimulators in improving skin quality in PXE, offering longer-lasting results and a high safety profile. However, further clinical trials with long-term follow-up are required to confirm its efficacy in PXE's skin laxity.
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Registered trials
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