Evidence map›Paper›PMID 39703060›Full record

ArticleEuropean journal of immunology2025

The Efficiency of Brain-Derived Neurotrophic Factor Secretion by mRNA-Electroporated Regulatory T Cells Is Highly Impacted by Their Activation Status.

Jasper Van den Bos, Ibo Janssens, Morgane Vermeulen, Amber Dams, Hans De Reu, Stefanie Peeters, Carole Faghel, Yousra El Ouaamari, Inez Wens, Nathalie Cools

Abstract read
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jasper Van den BosLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Ibo JanssensLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0001-8908-3110
Morgane VermeulenLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Amber DamsLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Hans De ReuLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Stefanie PeetersLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Carole FaghelLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Yousra El OuaamariLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Inez WensLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Nathalie CoolsLaboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

Funding

Fondation Charcot FCS-2020-JVDB7Fonds Wetenschappelijk Onderzoek G049320N
6 · The paper itself

Abstract

Genetic engineering of regulatory T cells (Tregs) presents a promising avenue for advancing immunotherapeutic strategies, particularly in autoimmune diseases and transplantation. This study explores the modification of Tregs via mRNA electroporation, investigating the influence of T-cell activation status on transfection efficiency, phenotype, and functionality. For this CD45RA

Indexed as

Brain-Derived Neurotrophic FactorLymphocyte ActivationRNA, MessengerT-Lymphocytes, RegulatoryElectroporationHumansSignal TransductionBDNF protein, humanBrain-Derived Neurotrophic FactorRNA, Messengerbrain‐derived neurotrophic factormRNA electroporationregulatory T cellsT‐cell engineering

Identifiers

PMID39703060
PMCPMC11830389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.