Evidence map›Paper›PMID 39702850›Full record

Trial reportTherapeutic innovation & regulatory science2025

Consumer Understanding of Prescription Drug Indications in Direct-to-Consumer Television Advertisements.

Helen W Sullivan, Kathryn J Aikin, Mihaela Johnson, Kate Ferriola-Bruckenstein

Erratum issuedAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Therapeutic innovation & regulatory science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Helen W SullivanUS Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA. helen.sullivan@fda.hhs.gov.
Kathryn J AikinUS Food and Drug Administration, 10903 New Hampshire Ave, Silver Spring, MD, 20993, USA.
Mihaela JohnsonRTI International, Research Triangle Park, NC, 27709, USA.
Kate Ferriola-BruckensteinRTI International, Research Triangle Park, NC, 27709, USA.

Funding

Intramural FDA HHS FD999999
6 · The paper itself

Abstract

backgroundPrescription drugs may be indicated to treat more than one medical condition, and companies may promote more than one indication in the same direct-to-consumer (DTC) ad. This study examined how presenting multiple prescription drug indications in one DTC television ad affects consumers' processing of drug information.

methodsWe conducted two studies with adults diagnosed with diabetes (Study 1, N = 408) or rheumatoid arthritis (Study 2, N = 411). We randomly assigned participants to view one of three television ads: primary indication only (Study 1: diabetic peripheral neuropathy; Study 2: rheumatoid arthritis), primary plus a similar secondary indication (Study 1: fibromyalgia; Study 2: psoriatic arthritis), or primary plus a dissimilar secondary indication (Study 1: generalized anxiety disorder; Study 2: ulcerative colitis).

resultsRemembering and understanding the primary indication was not significantly affected by the presence of a secondary indication (similar or dissimilar). Higher health literacy participants remembered and understood secondary indications.

conclusionsIncluding a second indication in DTC television ads does not appear to have detrimental effects and can increase awareness of the second indication for some participants. Industry and regulators should continue to ensure DTC promotion is truthful and non-misleading, irrespective of the number of indications presented.

Indexed as

Direct-to-Consumer AdvertisingHealth Knowledge, Attitudes, PracticePrescription DrugsTelevisionAdultAgedArthritis, RheumatoidDiabetes MellitusFemaleHealth LiteracyHumansMaleMiddle AgedPrescription DrugsAdvertisingComprehensionDirect-to-consumerPerceptionPrescription drugs

Identifiers

PMID39702850
PMCPMC11879756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.