ArticleEuropean journal of neurology2025
Evaluating gait and postural responses to subthalamic stimulation and levodopa: A prospective study using wearable technology.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- The Role of Ecological and Complex Gait and Postural Tasks in the Assessment of Subtle Deficits in Parkinson's Disease.Healthcare (Basel, Switzerland) · 2026Article
- Cortico-pallidal beta dynamics underlie impaired turning in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- From phenotype to biology: a multi-modal roadmap of biofluid, tissue, imaging, and digital biomarkers in Parkinson's disease.Translational neurodegeneration · 2026Review
- The Effects of Deep Brain Stimulation on Balance in Parkinson's Disease as Measured Using Posturography-A Narrative Review.Brain sciences · 2025Review
- Evaluating gait and postural responses to subthalamic stimulation and levodopa: A prospective study using wearable technology.European journal of neurology · 2025Article
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Authors and funding
12 authors.
Funding
Abstract
backgroundThe efficacy of subthalamic stimulation on axial signs of Parkinson's disease (PD) is debated in the literature. This study delves into the dynamic interplay of gait and posture, specifically probing their nuanced response to subthalamic stimulation and levodopa.
methodsWe used wearable sensor technology to examine alterations in the spatiotemporal parameters of gait and posture in individuals with PD before and 6 months after subthalamic deep brain stimulation (STN-DBS) surgery. Thirty-three subjects with PD were evaluated in two pre-operative and four post-operative conditions comprising OFF/ON medication and stimulation states. Standardized response mean (SRM) values were calculated to assess treatment responsiveness.
resultsSignificant improvements in spatiotemporal gait parameters, including speed, stride length, cadence, and turning, were observed following STN-DBS surgery. Quantitatively, stimulation outperformed levodopa in enhancing gait speed, stride length, and turning, as indicated by SRM. Levodopa moderately improved stride time variability and asymmetry, while stimulation alone demonstrated limited efficacy. Postural parameters exhibited minimal change following STN-DBS, although stimulation showed a slight benefit in certain postural aspects.
conclusionOur findings suggest positive effects of stimulation and levodopa on gait and postural parameters, with STN-DBS demonstrating superior efficacy in enhancing gait speed, stride length, and turning. However, gait variability remains unaddressed by current therapies, highlighting the need for novel treatments targeting regions beyond the basal ganglia.
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