Evidence map›Paper›PMID 39702758›Full record

ArticleCommunications medicine2024

Elevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers.

Hugo F Posada-Quintero, Bruce J Derrick, M Claire Ellis, Michael J Natoli, Christopher Winstead-Derlega, Sara I Gonzalez, Christopher M Allen, Matthew S Makowski, Brian M Keuski, Richard E Moon and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hugo F Posada-QuinteroDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA. hugo.posada-quintero@uconn.edu.ORCID http://orcid.org/0000-0003-4514-4772
Bruce J DerrickDepartment of Emergency Medicine, Duke University, Durham, NC, USA.
M Claire EllisDepartment of Emergency Medicine, Duke University, Durham, NC, USA.
Michael J NatoliDepartment of Anesthesiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0002-1870-532X
Christopher Winstead-DerlegaDepartment of Emergency Medicine, Duke University, Durham, NC, USA.
Sara I GonzalezDepartment of Emergency Medicine, Duke University, Durham, NC, USA.
Christopher M AllenDepartment of Emergency Medicine, Duke University, Durham, NC, USA.
Matthew S MakowskiDepartment of Anesthesiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0001-6486-771X
Brian M KeuskiDepartment of the Navy, Panama City, FL, USA.
Richard E MoonDepartment of Anesthesiology, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-4432-0332
John J FreibergerDepartment of Anesthesiology, Duke University, Durham, NC, USA.
Ki H ChonDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.

Funding

Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)T32HL160494 · NHLBI · DUKE UNIVERSITY · PI Jennifer L. Ingram, DAVID MARTIN MURDOCH · 2022 to 2026
$2.6M
NHLBI NIH HHS T32 HL160494
6 · The paper itself

Abstract

backgroundOxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO

methodsEDA is recorded during 50 subject exposures (26 subjects) to evaluate CNS-OT in immersed (head out of water) exercising divers in a hyperbaric chamber breathing 100% O

results32 subject exposures exhibit symptoms "definitely" or "probably" due to CNS-OT before the end of the exposure, whereas 18 do not. We obtain traditional and time-varying spectral indices (TVSymp) of EDA to determine its utility as predictive physio markers. Variations in EDA and heart rate (HR) for the last 5 min of the experiment are compared to baseline values prior to breathing O

conclusionsIn this retrospective analysis, TVSymp may have predictive value for CNS-OT with high sensitivity (1.0) but lower specificity (0.48). Additional work is being undertaken to improve the detection algorithm.

Identifiers

PMID39702758
PMCPMC11659611

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.