Evidence map›Paper›PMID 39702754›Full record

ArticleCommunications biology2024

Thermoresponsive gel embedding extracellular vesicles from adipose stromal cells improves the healing of colonic anastomoses following irradiation in rats.

Hadrien Alric, Noëlle Mathieu, Anna Sebbagh, Guillaume Peré, Christelle Demarquay, André Cronemberger, Arthur Berger, Benjamin Marcel, Claire Wilhelm, Florence Gazeau and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hadrien Alric *Laboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France. Hadrien.alric@aphp.fr.ORCID 0000-0002-0343-4440
Noëlle Mathieu *Laboratoire de Radiobiologie des Expositions Médicales, Institut de Radioprotection et de Sureté Nucléaire, Fontenay-Aux-Roses, France.
Anna SebbaghLaboratoire Matière et Systèmes Complexes, CNRS, UMR 7057, Université Paris Cité, Paris, France.ORCID 0000-0002-9717-2444
Guillaume PeréLaboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France.
Christelle DemarquayLaboratoire de Radiobiologie des Expositions Médicales, Institut de Radioprotection et de Sureté Nucléaire, Fontenay-Aux-Roses, France.
André CronembergerLaboratoire Matière et Systèmes Complexes, CNRS, UMR 7057, Université Paris Cité, Paris, France.
Arthur BergerLaboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France.
Benjamin MarcelLaboratoire Matière et Systèmes Complexes, CNRS, UMR 7057, Université Paris Cité, Paris, France.
Claire WilhelmLaboratoire PhysicoChimie Curie, Institut Curie, PSL Research University-Sorbonne Université-CNRS, Paris, France.
Florence GazeauLaboratoire Matière et Systèmes Complexes, CNRS, UMR 7057, Université Paris Cité, Paris, France.
Antoine MarianiLaboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France.
Mehdi KarouiLaboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France.
Olivier ClémentLaboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France.
Irami Araujo-FilhoDepartment of Surgery, Federal University of Rio Grande do Norte. Institute of Teaching, Research, and Innovation, Liga Contra o Cancer, Natal, Brazil.
Amanda K A Silva *Laboratoire Matière et Systèmes Complexes, CNRS, UMR 7057, Université Paris Cité, Paris, France.
Gabriel Rahmi *Laboratoire de Recherche en Imagerie du Vivant, PARCC, INSERM U970, Université Paris Cité, Paris, France.

Funding

European Research Council 852791
6 · The paper itself

Abstract

Anastomotic leak occurrence is a severe complication after colorectal surgery. Considering the difficulty of treating these leaks and their impact on patient care, there is a strong need for an efficient prevention strategy. We evaluated a combination of extracellular vesicles (EVs) from rat adipose-derived stromal cells with a thermoresponsive gel, Pluronic® F127 (PF-127) to prevent anastomotic leaks. The pro-regenerative and immunomodulatory potencies of EVs are assessed in vitro. In vivo efficacy are assessed in rat with a colonic anastomosis model after irradiation. Endoscopic, anatomical and histological data show a consistent effect of EVs + gel on the healing of colonic anastomosis. These results are illustrated by a smaller anastomotic ulcer size, less fibrosis and less inflammatory infiltrations in the EVs + gel group. This multi-modal investigation is the first to point-out the translational potential of EVs combined with PF-127 for the healing of high-risk colorectal anastomosis.

Indexed as

Anastomosis, SurgicalColonExtracellular VesiclesWound HealingAdipose TissueAnastomotic LeakAnimalsGelsMalePoloxamerRatsStromal CellsGelsPoloxamer

Identifiers

PMID39702754
PMCPMC11659299

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.