Evidence map›Paper›PMID 39702745›Full record

ArticleBasic & clinical pharmacology & toxicology2025

Decreased blood pressure with acute administration of quercetin in L-NAME-induced hypertensive rats.

Siluleko A Mkhize, Refentshe A Nthlane, Sanelisiwe P Xhakaza, Peter D Verhaert, Sooraj Baijnath, Aletta M E Millen, Frederic S Michel

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In one paragraph

Article in Basic & clinical pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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  6. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Siluleko A MkhizeWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-8351-6891
Refentshe A NthlaneWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-5161-5932
Sanelisiwe P XhakazaWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-5886-8131
Peter D VerhaertProteoFormiX BV, Vorselaar, Belgium.ORCID https://orcid.org/0000-0002-6921-087X
Sooraj BaijnathWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-7860-1779
Aletta M E MillenWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-4831-7336
Frederic S MichelWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0001-6247-6467

Funding

Faculty Research Committee (FRC) of the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa 001.401.8521101.0000000.000000 PHSMFR0South African National Research Foundation MND210430598430
6 · The paper itself

Abstract

Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear. We investigated the acute effects of quercetin on BP, aortic mechanical properties and vascular reactivity in female Sprague-Dawley (SD) rats. Hypertension was induced using L-NAME (40 mg/kg/day). Quercetin (4.5 mg/kg) was administered intravenously. Mechanical properties of the aortae were measured by echo-tracking in normotensive and hypertensive rats. L-NAME and quercetin quantities in the aorta were determined using AP-MALDI-MSI. Vascular reactivity was performed in mesenteric and renal arteries. L-NAME increased BP and PWVβ while decreasing strain. Quercetin decreased BP and ameliorated PWVβ in L-NAME-induced hypertensive rats. Ex vivo, the acetylcholine (ACh)-induced increase in tension at 100 μM was reduced in renal arteries when exposed to quercetin while phenylephrine (Phe)-induced contractile response was augmented. In quiescent rings of renal arteries incubated with L-NAME (10 μM) and TRAM-34 (1 μM), the ACh-induced vasoconstrictions were inhibited by quercetin. Quercetin resulted in concentration-dependent vasodilation in mesenteric arteries and increased its sensitivity to ACh-induced relaxations. Quercetin lowered BP in L-NAME-induced hypertensive rats, likely due to changes in aortic mechanical properties and relaxation of resistance arteries. Further research is warranted to clarify the acute effects of quercetin on renal arteries in this hypertensive model.

Indexed as

Blood PressureHypertensionNG-Nitroarginine Methyl EsterQuercetinRats, Sprague-DawleyVasoconstrictionVasodilationAcetylcholineAnimalsAntihypertensive AgentsAortaDisease Models, AnimalFemaleMesenteric ArteriesRatsRenal ArteryAcetylcholineAntihypertensive AgentsNG-Nitroarginine Methyl EsterQuercetinAP‐MALDI‐MSIblood pressureecho‐trackingquercetinvascular reactivity

Identifiers

PMID39702745
PMCPMC11659105

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.