ArticleMethods in molecular biology (Clifton, N.J.)2025
Mathematical Modeling for Oscillations Driven by Noncoding RNAs.
Article in Methods in molecular biology (Clifton, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this chapter, we first survey strategies for the mathematical modeling of gene regulatory networks for capturing physiologically important dynamics in cells such as oscillations. We focus on models based on ordinary differential equations with various forms of nonlinear functions that describe gene regulations. We next use a small system of a microRNA and its mRNA target to illustrate a recently discovered oscillator driven by noncoding RNAs. This oscillator has unique features that distinguish it from conventional biological oscillators, including the absence of an imposed negative feedback loop and the divergence of the periods. The latter property may serve crucial biological functions for restoring heterogeneity of cell populations on the timescale of days. We describe general requirements for obtaining the limit cycle oscillations in terms of underlying biochemical reactions and kinetic rate constants. We discuss future directions stemming from this minimal, noncoding RNA-based model for gene expression oscillation.
Indexed as
Identifiers
39702708What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.