ArticleHepatology international2025
Global, regional, and national temporal trends in incidence and mortality for liver cancer due to hepatitis B, 1990-2021: a decomposition and age-period-cohort analysis for the Global Burden of Disease Study 2021.
Article in Hepatology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The disease burden of ILD at the global, regional, and national levels from 1990 to 2021, and projections until 2035: the 2021 Global Burden of Disease study.Frontiers in medicine · 2025Pooled it
- National trends in acute viral hepatitis in China from 1990-2023: An analysis of the Global Burden of Disease 2023 update.Chinese medical journal · 2026Article
- Trends in the global burden of anemia associated with liver cirrhosis: an assessment from 1990 to 2021 and projections to 2045.Frontiers in public health · 2026Article
- Global, Regional, and National Burden and Trends of Hypertensive Heart Disease Among Women of Childbearing Age from 1992 to 2021.International journal of women's health · 2026Article
- The shift in Mosquito-borne diseases incidence across Asia-Pacific region (1992-2021): insights from an Age-Period-Cohort analysis using the global burden of disease study 2021.BMC public health · 2025Article
- Article
- Breaking bottlenecks: the future of hepatocellular carcinoma clinical trials and therapeutic targets.Hepatology international · 2025Review
- Global, regional, and national burden of breast cancer in young women from 1990 to 2021: findings from the global burden of disease study 2021.BMC cancer · 2025Article
- Epidemiological trends and projections to 2035 of hepatitis B burden in China, 1990-2021.PloS one · 2025Article
- Global, regional, and national burden of acute glomerulonephritis from 1990 to 2021 and future trend predictions until 2036: a systematic analysis using the Global Burden of Disease Study 2021.Frontiers in public health · 2025Article
- Global, regional, and national burden of hip fractures attributable to falls in older adults: changes from 1990-2021 and 2036 projections.Frontiers in public health · 2025Article
- Global burden of HIV, syphilis, and HBV infection among women of childbearing age and children under five: based on the Global Burden of Diseases Study 2021.Frontiers in public health · 2025Article
- The global burden of tuberculosis attributable to diet high in processed meat from 1990 to 2021: findings from the Global Burden of Disease Study 2021.Frontiers in nutrition · 2025Article
- Declining Mortality and Rising Disability From Low Bone Mineral Density in Postmenopausal Women in China and G20 Countries.Inquiry : a journal of medical care organization, provision and financingArticle
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12 authors.
Funding
Abstract
objectiveThis study comprehensively assessed the burden of liver cancer due to hepatitis B (LCHB) from 1990 to 2021, analyzing temporal trends in disease burden and associations with age, period and birth cohort.
methodsAge-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR) of LCHB from 1990 to 2021 were collected from the Global Burden of Disease (GBD) 2021. Joinpoint regression analysis estimated long-term trends. Age-period-cohort analysis evaluated the independent effects of age, period and cohort. Decomposition analysis elucidated the impact of population growth, aging and epidemiological changes on the burden.
resultsBetween 1990 and 2019, the ASIR and ASMR of LCHB witnessed an overall declining trend worldwide, with a notably higher burden in males compared to females. The highest ASIR and ASMR were observed in the middle socio-demographic index (SDI) region, while the lowest were in the low-middle SDI region, with substantial differences across countries. Age-period-cohort analysis revealed an initial increase in risk followed by a decline with advancing age, with the burden primarily affecting the elderly. Decomposition analysis indicated that population growth and aging were the primary drivers of the increase in incident cases and deaths.
conclusionsFrom 1990 to 2021, the ASIR and ASMR of LCHB decreased globally. However, population growth and aging contributed to an increase in the absolute numbers of incident cases and deaths. The risk burden increased with age, and favourable period and cohort effects were found in all SDI regions.
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