Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024
Effects of intermittent hand-foot hypothermia therapy on chemotherapy-induced peripheral neurotoxicity.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Limb cold therapy for preventing paclitaxel-induced peripheral neuropathy in breast cancer patients: a randomized controlled study.World journal of surgical oncology · 2026Trial
- Artificial hibernation: A new technique for protecting neural tissue and organs.Neural regeneration research · 2026Article
- Addressing the Needs of Breast Cancer Survivors.Current oncology reports · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
purposeChemotherapy-induced peripheral neuropathy (CIPN) is a common side effect in patients with breast cancer undergoing chemotherapy. This study aimed to assess the effects of three different intermittent hypothermia temperatures applied to the hands and feet on CIPN symptoms in patients with breast cancer undergoing chemotherapy.
methodsIn total, 108 patients were randomly divided into three experimental groups (n = 36). Patients wore cold gloves and foot covers (groups 1-3, three 10 °C intervals from 0 to - 30 °C) for 15 min before and after each infusion. CIPN symptoms and their interference with activities of daily living (ADL) were assessed before the intervention and after the third and sixth cycles. Hypothermia tolerability and safety were also evaluated.
resultsBaseline characteristics were similar across groups. After three intervention cycles, the scores were lower in group 3 than in group 1 for finger/hand numbness, toe/foot numbness, finger/hand/toe/foot discomfort, muscle/joint pain, and arm/leg weakness. After six intervention cycles, group 3 showed lower scores than group 1 for finger/hand tingling, toe/foot tingling, and difficulty maintaining balance. After six cycles of intervention, the influence of CIPN on ADL in all dimensions (except getting along with others) and the total score was lower in group 3 than in group 1. Additionally, CIPN symptoms and effects on activities of daily living were significant across time, groups, and interactions.
conclusionsIntermittent hand-foot therapy (- 20 to - 30 °C) was the most effective for improving symptoms and ability to perform day-to-day activities. All temperatures tested were well-tolerated and safe.
Indexed as
Identifiers
39702596What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.