Evidence map›Paper›PMID 39702576›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025

Epac2-mediated synaptic insertion of Ca

Xiaojie Liu, Yao Huang, Lianwei Mu, Vladislav Friedman, Thomas J Kelly, Ying Hu, Dong Yuan, Qing-Song Liu

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Epac2 activation drives calcium permeable-AMPA receptor accumulation, fueling the incubation of cocaine craving.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaojie LiuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA. xiaojieliu@mcw.edu.ORCID http://orcid.org/0000-0001-9843-1674
Yao HuangDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.
Lianwei MuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.
Vladislav FriedmanDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.ORCID http://orcid.org/0000-0002-5567-2520
Thomas J KellyDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.
Ying HuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.
Dong YuanDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA.
Qing-Song LiuDepartment of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, USA. qsliu@mcw.edu.ORCID http://orcid.org/0000-0003-1858-1504

Funding

Medical Scientist Training ProgramT32GM080202 · NIGMS · MEDICAL COLLEGE OF WISCONSIN · PI BARBIERI, JOSEPH T, SALZMAN, NITA H · 2010 to 2024
$5.7M
Mechanistic studies of phosphodiesterase inhibitors in cocaine addictionR01DA035217 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI LIU, QING-SONG · 2014 to 2023
$3.4M
Regulation of neuronal activity in the paraventricular thalamus by chronic morphineF31DA054759 · NIDA · MEDICAL COLLEGE OF WISCONSIN · PI FRIEDMAN, VLADISLAV · 2021 to 2024
$189k
NIDA NIH HHS R01 DA035217NIGMS NIH HHS T32 GM080202U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) F31DA054759U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA035217
6 · The paper itself

Abstract

The accumulation of GluA2-lacking Ca

Indexed as

CocaineCocaine-Related DisordersCravingGuanine Nucleotide Exchange FactorsNucleus AccumbensReceptors, AMPASynapsesAnimalsCalciumMaleRatsRats, Sprague-DawleySelf AdministrationCalciumCocaineGuanine Nucleotide Exchange FactorsRapgef4 protein, ratReceptors, AMPA

Identifiers

PMID39702576
PMCPMC11845495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.