Evidence map›Paper›PMID 39702518›Full record

ArticleCommunications biology2024

Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies.

Benjamin Hunter, Mengbo Li, Benjamin L Parker, Yen Chin Koay, Dylan J Harney, Evangeline Pearson, Jacob Cao, Gavin T Chen, Oneka Guneratne, Gordon K Smyth and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Right Heart Diastology, Where Are We Now?Circulation research · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Benjamin Hunter *Precision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0001-6100-9760
Mengbo Li *Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, VIC, Australia.ORCID 0000-0002-9666-5810
Benjamin L ParkerDepartment of Anatomy and Physiology, The University of Melbourne, Parkville, VIC, Australia.ORCID 0000-0003-1818-2183
Yen Chin KoayPrecision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia.
Dylan J HarneyCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-1148-5838
Evangeline PearsonPaediatric Oncology and Haematology, Oxford Children's Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, England.
Jacob CaoCentral Clinical School, Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
Gavin T ChenDepartment of Cardiology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.ORCID 0000-0002-6041-9749
Oneka GuneratneKolling Institute, Royal North Shore Hospital, and Charles Perkins Centre, Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia.
Gordon K SmythBioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, VIC, Australia.ORCID 0000-0001-9221-2892
Mark LaranceCharles Perkins Centre, The University of Sydney, Sydney, NSW, Australia.ORCID 0000-0002-8579-2267
John F O'SullivanPrecision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia. john.osullivan@sydney.edu.au.ORCID 0000-0001-8016-5128
Sean LalPrecision Cardiovascular Laboratory, The University of Sydney, Sydney, NSW, Australia. sean.lal@sydney.edu.au.ORCID 0000-0002-5841-560X

Funding

Biomedical Data Commons Workbench (BDCW)OT2OD030544 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SUBRAMANIAM, SHANKAR · 2020 to 2024
$3.2M
NIH HHS OT2 OD030544U.S. Department of Health & Human Services | National Institutes of Health (NIH) OT2-OD030544U.S. Department of Health & Human Services | National Institutes of Health (NIH) U2C-DK119886
6 · The paper itself

Abstract

The left and right ventricles of the human heart are functionally and developmentally distinct such that genetic or acquired insults can cause dysfunction in one or both ventricles resulting in heart failure. To better understand ventricle-specific molecular changes influencing heart failure development, we first performed unbiased quantitative mass spectrometry on pre-mortem non-diseased human myocardium to compare the metabolome and proteome between the normal left and right ventricles. Constituents of gluconeogenesis, glycolysis, lipogenesis, lipolysis, fatty acid catabolism, the citrate cycle and oxidative phosphorylation were down-regulated in the left ventricle, while glycogenesis, pyruvate and ketone metabolism were up-regulated. Inter-ventricular significance of these metabolic pathways was then found to be diminished within end-stage dilated cardiomyopathy and ischaemic cardiomyopathy, while heart failure-associated pathways were increased in the left ventricle relative to the right within ischaemic cardiomyopathy, such as fluid sheer-stress, increased glutamine-glutamate ratio, and down-regulation of contractile proteins, indicating a left ventricular pathological bias.

Indexed as

CardiomyopathiesHeart VentriclesMetabolomicsMyocardiumProteomicsAdultAgedFemaleHumansMaleMetabolomeMiddle AgedProteomeProteome

Identifiers

PMID39702518
PMCPMC11659555

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.