Evidence map›Paper›PMID 39702461›Full record

ArticleCommunications medicine2024

A prospective cohort study of cochlear implantation as a treatment for tinnitus in post-lingually deafened individuals.

Qian Wang, Michelle R Kapolowicz, Jia-Nan Li, Fei Ji, Wei-Dong Shen, Fang-Yuan Wang, Wei Chen, Wei-Wei Guo, Chi Zhang, Ri-Yuan Liu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qian Wang *Senior Department of Otolaryngology-Head and Neck Surgery, the First Medical Center of PLA General Hospital, Beijing, 100853, China.
Michelle R Kapolowicz *Center for Hearing Research, Departments of Anatomy and Neurobiology, Biomedical Engineering, Cognitive Sciences, Otolaryngology-Head and Neck Surgery, University of California Irvine, Irvine, California, CA, 92697, USA.ORCID http://orcid.org/0000-0003-4404-5270
Jia-Nan Li *Senior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Fei JiSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Wei-Dong ShenSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Fang-Yuan WangSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Wei ChenSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Wei-Wei GuoSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Chi ZhangSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Ri-Yuan LiuSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Miao ZhangSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China.
Meng-Di HongSenior Department of Otolaryngology-Head and Neck Surgery, the First Medical Center of PLA General Hospital, Beijing, 100853, China.
Ai-Ting ChenSenior Department of Otolaryngology-Head and Neck Surgery, the First Medical Center of PLA General Hospital, Beijing, 100853, China.
Fan-Gang ZengCenter for Hearing Research, Departments of Anatomy and Neurobiology, Biomedical Engineering, Cognitive Sciences, Otolaryngology-Head and Neck Surgery, University of California Irvine, Irvine, California, CA, 92697, USA. fzeng@uci.edu.ORCID http://orcid.org/0000-0002-4325-2780
Shi-Ming YangSenior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, 100048, China. yangshiming@301hospital.com.cn.

Funding

U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5R01 DC015587
6 · The paper itself

Abstract

backgroundCochlear implants have helped over one million individuals restore functional hearing globally, but their clinical utility in suppressing tinnitus has not been firmly established.

methodsIn a decade-long study, we examined longitudinal effects of cochlear implants on tinnitus in 323 post-lingually deafened individuals including 211 with pre-existing tinnitus and 112 without tinnitus. The primary endpoints were tinnitus loudness and tinnitus handicap inventory. The secondary endpoints were speech recognition, anxiety and sleep quality.

resultsHere we show that after 24 month implant usage, the tinnitus cohort experience 58% reduction in tinnitus loudness (on a 0-10 scale from 4.3 baseline to 1.8 = -2.5, 95% CI: -2.7 to -2.2, p = 3 x 10

conclusionsThe present result shows that cochlear implantation can offer an alternative effective treatment for tinnitus. The present result also identifies a critical need in developing always-on and atraumatic devices for tinnitus patients, including potentially those with normal hearing.

Identifiers

PMID39702461
PMCPMC11659473

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.