Evidence map›Paper›PMID 39702453›Full record

ArticleBMC research notes2024

The impact of preoperative stress on age-related cognitive dysfunction after abdominal surgery: a study using a rat model.

Natsuki Nakagoshi, Fabricio M Locatelli, Sonoe Kitamura, Seiji Hirota, Takashi Kawano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Natsuki NakagoshiDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko-cho, Kohasu, Nankoku, 783-8505, Kochi, Japan.
Fabricio M LocatelliDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko-cho, Kohasu, Nankoku, 783-8505, Kochi, Japan.
Sonoe KitamuraDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko-cho, Kohasu, Nankoku, 783-8505, Kochi, Japan.
Seiji HirotaDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko-cho, Kohasu, Nankoku, 783-8505, Kochi, Japan.
Takashi KawanoDepartment of Anesthesiology and Intensive Care Medicine, Kochi Medical School, Oko-cho, Kohasu, Nankoku, 783-8505, Kochi, Japan. takashika@kochi-u.ac.jp.

Funding

Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science 18H02898
6 · The paper itself

Abstract

objectiveThis study examines the impact of preoperative stress on postoperative neuroinflammation and associated cognitive dysfunction, with a focus on aged individuals. The goal is to determine whether managing preoperative stress can enhance postoperative outcomes and lower the risk of cognitive impairment.

resultsIn aged rats, preoperative restraint stress significantly worsened neuroinflammation and cognitive deficits following abdominal surgery. Elevated levels of pro-inflammatory cytokines were observed in the hippocampus and medial prefrontal cortex two days post-surgery, and these effects persisted for twenty-eight days. In contrast, adult rats did not show significant changes in neuroinflammation or cognitive function due to preoperative restraint stress. An ex vivo analysis indicated that hippocampal microglia from aged rats exhibited an intensified proinflammatory response to lipopolysaccharide stimulation, further heightened by preoperative restraint stress. These findings suggest that managing preoperative stress could mitigate these adverse effects, leading to better postoperative recovery and cognitive health in elderly patients.

Indexed as

AbdomenCognitive DysfunctionStress, PsychologicalAgingAnimalsCytokinesDisease Models, AnimalHippocampusMaleMicrogliaNeuroinflammatory DiseasesPostoperative Cognitive ComplicationsPostoperative ComplicationsPrefrontal CortexPreoperative PeriodRatsCytokinesAged ratsCognitive dysfunctionNeuroinflammationPostoperative deliriumPreoperative stress

Identifiers

PMID39702453
PMCPMC11660812

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.