ArticleJournal of orthopaedic surgery and research2024
Asperuloside alleviates osteoporosis by promoting autophagy and regulating Nrf2 activation.
Article in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 4 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Predictors of delayed union after surgical treatment in patients with osteoporotic vertebral compression fractures: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Effectiveness of anabolic and anti-resorptive agents for preventing postmenopausal osteoporosis fractures: a systematic review and network meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Optimal resistance training parameters for improving bone mineral density in postmenopausal women: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Efficacy and safety of sequential therapy for primary osteoporosis with bone formation promoters followed by bone resorption inhibitors: a meta-analysis.Journal of orthopaedic surgery and research · 2025Pooled it
- Macrophage polarization-related genes with potential causal roles in osteoporosis: a multi-omics Mendelian randomization study.Journal of orthopaedic surgery and research · 2026Article
- miR-1290 serves as a potential biomarker for osteoporotic fracture and regulates osteoblast function by targeting KDM5A.Journal of orthopaedic surgery and research · 2026Article
- HOXA7 Impairs Osteogenic Differentiation via p38/JNK Signaling: Implications for Osteoporosis.Journal of musculoskeletal & neuronal interactions · 2026Article
- The relationship between the polymorphisms and mutations of OPG gene and bone metabolism in postmenopausal women in northwest China.Journal of orthopaedic surgery and research · 2026Article
- ZM-306416 prevents ovariectomy-induced bone loss by promoting osteoblastogenesis and inhibiting osteoclastogenesis.Journal of orthopaedic surgery and research · 2026Article
- LncRNA CASC15 serves as a diagnostic biomarker for postmenopausal osteoporotic fractures and its knockdown enhances HBMSC osteogenic differentiation via miR-152-3p.Journal of orthopaedic surgery and research · 2026Article
- Diagnostic value and role in promoting fracture healing of deregulated circulating miR-204 in patients with osteoporotic fractures.Journal of orthopaedic surgery and research · 2026Article
- Integrating BMSC-inlaid GelMA hydrogels and melatonin-loaded PLGA microspheres into silk fibroin/nanohydroxyapatite scaffolds to repair osteoporotic bone defects.Journal of orthopaedic surgery and research · 2026Article
- Deer Antler Extract Promotes Osteoblast Differentiation and Improves Bone Microarchitecture in an Ovariectomy-Induced Osteoporosis Model.Preventive nutrition and food science · 2026Article
- miR-202-5p mitigates the advancement of osteoporosis through the regulation of PTEN.Journal of orthopaedic surgery and research · 2025Article
- High prevalence and underdiagnosis of osteoporosis in total hip arthroplasty candidates: a comprehensive assessment using bone mineral density, trabecular bone score, and bone turnover markers.Journal of orthopaedic surgery and research · 2025Article
- Localized therapeutic strategy based on microRNA-21-loaded mesoporous silica nanoparticles hydrogel improves bone repair in medication-related osteonecrosis of the jaw.Journal of orthopaedic surgery and research · 2025Article
- MiR-328-5p/BCL7A axis is involved in fracture healing by modulating osteoblast function.Journal of orthopaedic surgery and research · 2025Article
- The N-butanol extract of modified Yanghe decoction alleviates ferroptosis in bone marrow mesenchymal stem cells in glucocorticoid-induced osteoporosis by activating the HIF-1α/GPX4 signaling pathway.Journal of orthopaedic surgery and research · 2025Article
- miR-629-3p affects postmenopausal osteoporosis through targeted regulation of BACH1.Journal of orthopaedic surgery and research · 2025Article
- Effects of modified vertebral bone quality score and paravertebral muscle mass on multiple osteoporotic vertebral compression fractures: a retrospective multicenter cohort study.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundOsteoporosis is a metabolic bone disease that has a common occurrence in postmenopausal women. Asperuloside (ASP) has been reported to exert anti-inflammatory and anti-oxidative effects in numerous diseases, such as rheumatoid arthritis and acute lung injury. However, whether ASP plays a role in osteoporosis has not been addressed.
methodsIn vivo, ovariectomy (OVX) was used to induce mouse osteoporosis. Then, the mice were treated with 20 and 40 mg/kg ASP. In vitro, MC3T3-E1 cells were treated with 0, 1, 10, 20, 40 and 80 µM ASP. We chose 20 and 40 µM for further experiments due to no significant effects on cell viability.
resultsThe data indicated that ASP reduced osteoporosis in OVX mice and promoted osteogenic differentiation and mineralization in MC3T3-E1 cells. In addition, we explored that ASP protected against osteoporosis via inducing autophagy and activating Nrf2.
conclusionASP alleviates OVX-induced osteoporosis by promoting autophagy and regulating Nrf2 activation.
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