Evidence map›Paper›PMID 39702278›Full record

ArticleJournal of experimental & clinical cancer research : CR2024

FOLR2

Yuxin He, Jiayu Wang, Zilin Deng, Huang Feng, Mingzhan Du, Deqing Zhang, Guangbo Zhang, Tongguo Shi, Weichang Chen

Abstract read
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. FOLR2Cell communication and signaling : CCS · 2025
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuxin HeJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, 215000, China.
Jiayu WangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, 215000, China.
Zilin DengJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, 215000, China.
Huang FengDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Mingzhan DuDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Deqing ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Guangbo ZhangJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, 215000, China.
Tongguo ShiJiangsu Institute of Clinical Immunology, The First Affiliated Hospital of Soochow University, 178 East Ganjiang Road, Suzhou, 215000, China. shitg@suda.edu.cn.
Weichang ChenDepartment of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China. weichangchen@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe immune landscape associated with different subtypes of intestinal metaplasia (IM) and early gastric cancer (EGC) remains unclear. This study aimed to investigate the immune landscape of complete intestinal metaplasia (CIM), incomplete intestinal metaplasia (IIM), and EGC, as well as the underlying mechanisms of EGC progression.

methodsGastric biopsy samples were collected from five patients with CIM, six patients with IIM, and four patients with EGC, followed by single-cell RNA sequencing. Multiplex immunohistochemical staining was employed to validate the samples from the aforementioned patients. To elucidate the potential mechanisms involved, in vitro coculture experiments were conducted using FOLR2

resultsFive subpopulations of macrophages were identified in CIM, IIM and EGC samples. FOLR2

conclusionsOur work provides an understanding of the potential mechanisms underlying the malignant transformation of IM mediated by FOLR2

Indexed as

Disease ProgressionMacrophagesSingle-Cell AnalysisStomach NeoplasmsCD8-Positive T-LymphocytesFemaleHumansMaleMetaplasiaMiddle AgedCD8+T cellsEarly gastric cancerFOLR2+ macrophagesIntestinal metaplasiaMalignant transformationSingle-cell RNA sequencing

Identifiers

PMID39702278
PMCPMC11657096

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.