SynthesisEuropean journal of medical research2024
Impact of hematologic inflammatory markers on the prognosis of geriatric hip fracture: a systematic review and meta-analysis.
Synthesis in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Systemic Inflammatory Indexes as Predictors of Delirium, Thromboembolic Events, and Mortality After Hip Fracture and Major Orthopedic Surgery: A Meta-Analysis.Journal of Korean medical science · 2026Pooled it
- Association of multidimensional biomarkers of immune, nutritional, inflammatory, and metabolic status with postoperative outcomes in older hip fracture patients: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Predictive value of prognostic nutritional index for the long-term prognosis of elderly patients with fracture: a systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- Evaluation of short- and long-term mortality prediction in patients undergoing hip fracture surgery using a biomarker-based interpretable predictive modeling approach: a retrospective cohort analysis.BMC medical informatics and decision making · 2026Article
- Red cell distribution width and modified 5-item frailty index to predict short-term mortality in patients undergoing surgery for hip fracture.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- The 24-Hour Window: How Time to Admission Reshapes the Impact of Surgical Delay on Mortality in Elderly Hip Fracture.Journal of clinical medicine · 2026Article
- Systemic immune-inflammatory index is independently associated with two-year mortality after periprosthetic femoral fracture.BMC musculoskeletal disorders · 2026Article
- Inflammatory Biomarkers Following Orthopedic Surgery: Current Evidence, Clinical Applications, and Future Perspectives-A Narrative Review.Journal of clinical medicine · 2026Review
- A three-biomarker panel for frailty prediction and risk stratification in institutionalized older adults: a multicenter validation study.European geriatric medicine · 2026Article
- Risk factors for mortality in patients following total hip arthroplasty and hemiarthroplasty due to femoral neck fractures.Journal of orthopaedics · 2026Article
- Prognostic value of nine inflammatory biomarkers for 30-day mortality in critically ill elderly patients with osteoporotic hip fracture.Scientific reports · 2026Article
- Blood urea nitrogen to albumin ratio and 1-year mortality after hip fracture surgery in older adults: a retrospective cohort study.Frontiers in medicine · 2026Article
- Association of the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) Score with 3-Month Outcomes After Lumbar Medial Branch Radiofrequency Ablation: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2025Article
- Systemic Inflammation in Hip Fracture and Osteoarthritis: Insights into Pathways of Immunoporosis.International journal of molecular sciences · 2025Article
- Crystal Ball in a Blood's Drop: Unlocking Hidden Prognostic Power in the Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR) for Elderly Hip Fracture Patients.Journal of clinical medicine · 2025Article
- Immunomodulatory factors CRP/albumin ratio and NLR predict post-spinal surgery infection.Frontiers in surgery · 2025Article
- Assessing surgical trauma in robot-assisted pelvic fracture fixation: the role of the systemic immune-inflammatory index.Frontiers in surgery · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGeriatric hip fractures pose a significant health burden, and inflammation may play a role in the short- and long-term prognosis. However, the prognostic significance of hematologic inflammatory markers in geriatric patients with fractures is not understood. The aim of this systematic review and meta-analysis was to assess the prognostic implications of systemic inflammatory markers on the long-term mortality of older patients with hip fractures.
methodsPubMed, EMBASE, and Cochrane CENTRAL were searched from inception to December 19, 2023. Prospective, retrospective cohort, and case-control studies investigating the prognostic impact of hematologic inflammatory markers on mortality after hip fracture were eligible. Pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were calculated to determine the associations between the markers and mortality risk, with heterogeneity assessed by I
resultsUltimately, 7 retrospective studies involving a total of 7212 patients were included. The meta-analysis revealed that the neutrophil-to-lymphocyte ratio (NLR) (HR = 1.04, 95% CI 1.02-1.08), systemic immune-inflammatory index (SII) (HR = 1.03, 95% CI 1.01-1.05), and red cell distribution width (RDW) (HR = 1.07, 95% CI 1.01-1.14) independently correlated with increased long-term mortality.
conclusionsElevated NLR, SII, and RDW are independently associated with increased long-term mortality in older patients with hip fractures. These findings imply the potential value of incorporating these inflammatory indicators to aid in prognostic stratification of geriatric patients with hip fractures.
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