Evidence map›Paper›PMID 39702258›Full record

ArticleBMC research notes2024

Comparison of nasopharyngeal bacteriological profile between patients with diabetes and healthy individuals in Accra, Ghana.

Michael S Dei-Dzeha, Nicholas T K D Dayie, Yacoba Atiase, Bismark B Baah, Patience B Tetteh-Quarcoo, Mary-Magdalene Osei, Grace O Semevor, Isaac Okyere, Fleischer C N Kotey, Eric S Donkor

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Michael S Dei-DzehaDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Nicholas T K D DayieDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Yacoba AtiaseDepartment of Medicine, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Bismark B BaahDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Patience B Tetteh-QuarcooDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Mary-Magdalene OseiDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Grace O SemevorDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Isaac OkyereDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Fleischer C N KoteyDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana.
Eric S DonkorDepartment of Medical Microbiology, University of Ghana Medical School, P.O. Box KB 4236, Accra, Ghana. esampane-donkor@ug.edu.gh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe nasopharynx is characterised by a rich microbial diversity, making it an important endogenous reservoir for respiratory infections. People living with diabetes (PLWD) have a high risk for acquisition of respiratory tract infections, but their nasopharyngeal bacterial flora have rarely been investigated.

aimTo investigate the nasopharyngeal bacterial flora among PLWD and non-diabetics at the Korle Bu Teaching Hospital in Accra. METHODOLOGY: This study was a case-control one, involving 130 each of PLWD and non-diabetics. Nasopharyngeal swab specimens were obtained from the participants and cultured for bacteria, which were identified using MALDITOF mass spectrometry.

resultsThe bacterial flora present in the anterior nares of the participants of both study groups was characterised by a rich diversity, comprising both Gram-positives and Gram-negatives. In the diabetics, the dominant bacteria were Acinetobacter baumannii (19.6%), Staphylococcus epidermidis (18.12%), Staphylococcus aureus (15.2%), and Rahnella aquatilis (12.3%). In the control group, however, the dominant bacteria were Staphylococcus epidermidis (21.9%), Staphylococcus aureus (19.0%), Proteus mirabilis (10.9%), Pseudomonas aeruginosa (10.2%), Acinetobacter baumannii (8.8%), and Enterobacter cloacae (7.2%). Between groups, Acinetobacter baumannii (19.6% vs. 8.8%, p = 0.014) and Rahnella aquatilis (12.3% vs. 0.0%, p < 0.001) recorded a significantly higher prevalence in the diabetes group than in the control group. On the contrary, Klebsiella pneumoniae (0.0% vs. 4.4%, p = 0.003), Proteus mirabilis (2.2% vs. 10.9%, p = 0.006), and Pseudomonas aeruginosa (0.7% vs. 10.2%, p < 0.001) had significantly lower prevalence than in the control group.

conclusionThe nasopharyngeal bacterial flora of PLWD in Accra seems to have comparable diversities with those of non-diabetics. Nonetheless, the PLWD had a higher carriage rate of Acinetobacter baumannii but seem to have some protection against carriage of Klebsiella pneumoniae, Proteus mirabilis, and Pseudomonas aeruginosa.

Indexed as

Diabetes MellitusNasopharynxAdultAgedBacteriaCase-Control StudiesFemaleGhanaHumansMaleMiddle AgedRespiratory Tract InfectionsYoung AdultBacteriological profilesDiabetesNasopharynxPLWD

Identifiers

PMID39702258
PMCPMC11658440

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.