ArticleCancer cell international2024
MicroRNA networks in prolactinoma tumorigenesis: a scoping review.
Article in Cancer cell international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Liquid Biopsy in Pituitary Neuroendocrine Tumors-Potential Biomarkers for Diagnosis, Prognosis, and Therapy.International journal of molecular sciences · 2025Review
- Serum miR-130a-3p and miR-326: Correlation with Airway Inflammation and Prognostic Implications in Pediatric Bronchial Asthma.Journal of asthma and allergy · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlactinoma is the leading type of pituitary adenoma. Aside from the mass-like effect of prolactinoma, its hormonal effect is the main pathological cause of endocrine dysregulation and infertility. The dopamine agonist administration and surgical resection are the current mainstream anti-neoplastic treatments for affected patients; however, tumor fibrosis, tumor invasion, dopamine agonist resistance, and gain prolactinomas are clinical challenges for treating affected patients. Therefore, there is a need to develop novel treatments for these patients. Although growing evidence has highlighted the significance of dysregulated microRNA (miRNA) expression in various malignancies, no study has systematically investigated the significance of miRNA networks and their therapeutic potential in prolactinoma. For this aim, the current scoping review was performed according to the systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) guideline. MAIN BODY: The systematic study on PubMed, Web of Science, Scopus, and Embase databases has shown that miR-200c, miR-217, miR-93a, miR-93, miR-1299, and miR-9 are the oncogenic miRNAs and miR-137, miR-145-5p, miR-197-3p, miR-29a-3p, miR-489, miR-199a-5p, miR-124, miR-212, miR-129-5p, miR-130a-3p, miR-326, miR-432, miR-548c-3p, miR-570, miR-15, miR-16, miR-26a, miR-196a2, and let-7a are tumor-suppressive miRNAs in prolactinoma tumorigenesis.
conclusionIn summary, inhibiting the oncogenic miRNAs and ectopic expression of tumor-suppressive miRNAs can decrease prolactin secretion, reduce tumor invasion and migration, enhance dopamine agonist efficacy, and inhibit prolactinoma development. These findings can serve as a blueprint for future translational studies investigating miR-based therapeutics for prolactinoma.
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