SynthesisBMC infectious diseases2024
Prevalence, clinical characteristics, and treatment outcomes of childhood tuberculosis in Nigeria: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Pediatric Tuberculosis in North Kivu: The Urgency of a Targeted Response to a Forgotten Childhood Disease.Public health challenges · 2026Review
- Integrated surveillance of polio-negative acute flaccid paralysis cases for childhood tuberculosis: a novel GeneXpert-based screening approach in Rivers State, Nigeria.BMC infectious diseases · 2026Article
- TAK1 phosphorylation mediates macozinone (PBTZ169) induced innate immune activation against tuberculosis.mSphere · 2025Article
- Clinical Characteristics and Risk Factors of Tuberculosis in Children and Adolescents in Xinjiang, China: A Retrospective Analysis.Tropical medicine and infectious disease · 2025Article
- Clinical characteristics and prognostic outcomes of pediatric tuberculosis in a tertiary care center in China: a 10-year retrospective cohort.IJID regions · 2025Article
- Undiagnosed burden of latent tuberculosis, active tuberculosis and tuberculosis-HIV co-infections in Africa-status quo, needs, priorities, and opportunities.IJID regions · 2025Review
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Authors and funding
12 authors.
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Abstract
backgroundTuberculosis (TB), caused by Mycobacterium tuberculosis, is a leading cause of infection-related deaths worldwide. Children with underdeveloped immune systems are particularly vulnerable, experiencing symptoms akin to common childhood illnesses. Early diagnosis and treatment typically yield positive outcomes. In Nigeria, childhood TB is underreported, complicating accurate burden assessment. This review synthesises and presents evidence on the disease prevalence among children in Nigeria, identifies clinical characteristics, and evaluates the effectiveness of treatment regimens and outcomes. METHODOLOGY: A comprehensive systematic search across electronic databases was conducted to retrieve studies on the prevalence, characteristics, diagnostic criteria, and treatment outcomes of childhood tuberculosis in Nigeria. Study registration, data extraction and quality assessment followed standardized guidelines. The meta-analysis used a random-effects model to determine prevalence and mean treatment outcomes. Statistical heterogeneity was assessed using the I² statistic, and publication bias was evaluated with Egger's test (p = 0.127) and a funnel plot.
resultsThis review and meta-analysis of 22 studies, primarily retrospective (77%) and cross-sectional (18.20%), involving 1,162,936 participants aged 0-18 years, found a pooled prevalence of 20.82% (95% CI: 8.55-36.64)) with high heterogeneity (I
conclusionThe burden of childhood tuberculosis in Nigeria is significant, even as diagnostic limitations pose constraints. The findings highlight the need for stronger health system collaborations to improve the quality of care offered to children diagnosed with TB. Future research should standardize diagnostic criteria and methodologies for consistent and reliable prevalence estimates. More longitudinal studies are necessary to comprehend the trend and pattern for the heightened prevalence and subpar treatment outcomes of childhood tuberculosis in Nigeria. PROSPERO ID: CRD42024586765.
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