Evidence map›Paper›PMID 39702075›Full record

ArticleBMC ophthalmology2024

Comparison of efficacy and safety between gonioscopy-assisted transluminal trabeculotomy and trabeculectomy for primary open-angle glaucoma treatment: a retrospective cohort study.

Leyi Wang, Chen Wang, Pengyun Wang, Chenyang Dai, Rachita Kurmi, Wenzhe Zhang, Jiayin Wu, Hui Guo

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leyi WangDepartment of Ophthalmology, Qilu Hospital of Shandong University, Wenhua Xi Road 107, Jinan, 250012, Shandong, PR China.
Chen WangDepartment of Ophthalmology, Qilu Hospital of Shandong University, Wenhua Xi Road 107, Jinan, 250012, Shandong, PR China.
Pengyun WangDepartment of Ophthalmology, Qilu Hospital of Shandong University, Wenhua Xi Road 107, Jinan, 250012, Shandong, PR China.
Chenyang DaiDepartment of Ophthalmology, Qilu Hospital of Shandong University, Wenhua Xi Road 107, Jinan, 250012, Shandong, PR China.
Rachita KurmiDepartment of Ophthalmology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250002, PR China.
Wenzhe ZhangDepartment of Ophthalmology, Qilu Hospital of Shandong University, Wenhua Xi Road 107, Jinan, 250012, Shandong, PR China.
Jiayin WuDepartment of Ophthalmology, Qilu Hospital of Shandong University, Wenhua Xi Road 107, Jinan, 250012, Shandong, PR China.
Hui GuoDepartment of Ophthalmology, Qilu Hospital of Shandong University, Wenhua Xi Road 107, Jinan, 250012, Shandong, PR China. guohui@sdu.edu.cn.

Funding

National Natural Science Foundation of China 82101088Natural and Science Foundation of Shandong Province ZR2023LSW026
6 · The paper itself

Abstract

backgroundTrabeculectomy (TRAB) traditionally has been the gold-standard surgical treatment for primary open-angle glaucoma (POAG), while gonioscopy-assisted transluminal trabeculotomy (GATT) is an emerging minimally invasive surgery used for the treatment of various open-angle glaucoma (OAG) types. In this study, we aimed to compare the efficacy and safety between GATT and TRAB for the treatment of POAG.

methodsThis cohort study included eyes with POAG that underwent a single GATT (30 eyes) or TRAB (34 eyes). Follow-up was conducted at 1 day, 1 week, and 1, 3, 6, and 12 months postoperatively. Intraocular pressure (IOP), the numbers of glaucoma medication, visual field mean deviation, peripapillary retinal nerve fiber layer thickness, surgical time, and complications were analyzed. Success criteria were defined as IOP ≤ 21 mmHg and ≥ 20% IOP reduction from baseline. Qualified and complete surgical success rates were also compared.

resultsIOP and antiglaucoma drug use decreased significantly at 12 months postoperatively in the both groups (P < 0.001), with no significant differences between the two groups pre- and postoperatively (P > 0.05). The success rates at 12 months were 70% (95% confidence interval [CI] = 52.6-87.4%) in the GATT group and 76.5% (95% CI = 61.4-91.5%) in the TRAB group (P = 0.559).Visual field loss remained unchanged at 12 months postoperatively compared with preoperative levels in both groups (P > 0.05); however, peripapillary retinal nerve fiber layer thickness decreased significantly at 12 months postoperatively compared with preoperative levels in the GATT group (P < 0.001). The most frequent complications after TRAB and GATT were bleb-related complications and hyphema, respectively.

conclusionsGATT demonstrated an efficacy comparable to that of TRAB for the treatment of POAG with regards to lowering IOP, reducing medication use, and preserving visual fields. Thus, GATT is a minimally invasive technique that enables an effective and safe decrease in IOP.

Indexed as

Glaucoma, Open-AngleGonioscopyIntraocular PressureTrabeculectomyAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomeVisual AcuityVisual FieldsGonioscopy-assisted transluminal trabeculotomyPrimary open-angle glaucomaSingle procedureTrabeculectomy

Identifiers

PMID39702075
PMCPMC11660675

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.