SynthesisBMC musculoskeletal disorders2024
Tranexamic acid administration in total shoulder arthroplasty: a systematic review and meta-analysis.
Synthesis in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of tranexamic acid during bariatric surgery: an updated systematic review and meta-analysis of 10 comparative studies.BMC surgery · 2025Pooled it
- Systematic reviews on tranexamic acid in shoulder arthroplasty frequently exhibit reporting bias.JSES reviews, reports, and techniques · 2026Review
- Tranexamic acid utilization remains low in anatomical and reverse total shoulder arthroplasty despite decreased postoperative complications: A propensity-matched analysis.Shoulder & elbow · 2026Article
- Impact of intravenous tranexamic acid administration on reduction mammoplasty outcomes.JPRAS open · 2026Article
- Tranexamic acid in shoulder surgery: a comprehensive review of efficacy, safety, and clinical use.JSES reviews, reports, and techniques · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe effects of tranexamic acid (TXA) in total shoulder arthroplasty (TSA) are controversial. The objective of this study was to investigate the efficacy and safety of TXA in TSA.
methodsA systematic review and meta-analysis of TXA in TSA was carried out, and 5 trials including 372 patients were identified from PubMed (1966 to March 2024), Cochrane Central Register of Controlled Trials (March 2024), Embase (1974 to March 2024) and Web of Science (1995 to March 2024). Only randomized controlled trials (RCTs) were enrolled. Review Manager (RevMan, version 5.4, the Cochrane Collaboration, 2020) was used for statistical analysis. Primary outcomes were blood loss volume and allogenic blood transfusion rate. Secondary outcomes were drain out, postoperative change in hemoglobin (Hb), hospital stay, operation time, visual analogue score (VAS) pain score and complications.
resultsThis study found significant reduction in blood loss volume (MD = -269.06 ml; 95% CI = -367.25 to -170.87, P < 0.01), drain out (MD = -106.99 ml; 95% CI = -138.24 to -75.75, P < 0.001) at postoperative 1d, and postoperative change in hemoglobin (Hb) (MD = -0.40 g/dl; 95% CI = -0.94 to -0.14, P < 0.001) at postoperative 1d with the use of TXA. No significant differences in blood transfusion rate, hospital stay, operation time and complication rate between TXA and control groups.
conclusionsThe use of TXA in TSA reduces blood loss significantly. Further researches with large sample size are needed to investigate the effect and safety of TXA for shoulder arthroplasty in the revision TSA.
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