ArticleBMC pediatrics2024
Hospitalized children with influenza A before, during and after COVID-19 pandemic: a retrospective cohort study.
Article in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Hypertransaminasemia Is a Marker of Severity in Children Hospitalized for Influenza.Influenza and other respiratory viruses · 2026Article
- Metagenomic surveillance reveals off-season circulation of respiratory viruses during the COVID-19 pandemic in Salvador, Brazil.New microbes and new infections · 2026Article
- The Impact of the COVID-19 Pandemic on the Clinical Course of Influenza in Hospitalised Children in the Years 2017-2025.Life (Basel, Switzerland) · 2026Article
- Clinical outcomes of influenza in individuals aged ≤20 years before and after COVID-19: a national analysis of mortality and complications.Pediatric research · 2026Article
- Clinical Characteristics of Paediatric RSV, Influenza, and SARS-CoV-2 Infections: Insights from Three Consecutive Seasons.Viruses · 2025Article
- Article
- Hospitalizations trends and co-infection patterns for respiratory virus infections in children in central China 2015 to 2023: a longitudinal surveillance study.BMC infectious diseases · 2025Article
- Characteristics of children with influenza admitted to a pediatric hospital in Greece during the 2022/2023 and 2023/2024 seasons.European journal of pediatrics · 2025Observational
- Clinical and Paraclinical Peculiarities of SARS-CoV-2 and Influenza Infections in Children: A Comparative Study.Life (Basel, Switzerland) · 2025Article
- Hospitalizations and In-Hospital Fatality Among Influenza Patients in the Pre-Pandemic and COVID-19 Pandemic Periods.Journal of clinical medicine · 2025Article
- Pediatric early warning score and unplanned readmission with influenza at emergency observation room.Frontiers in pediatrics · 2025Article
- Clinical features of dengue-associated myositis in children: a retrospective study.Jornal de pediatriaObservational
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5 authors.
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Abstract
contextSince the outbreak of COVID-19 in late 2019, the transmission dynamics and clinical presentation patterns of influenza A (Flu A) virus have undergone changes.
objectivesThis article conducted a comparative analysis in clinical characteristics and laboratory results of pediatric patients with Flu A before, during, and after the COVID-19 pandemic.
methodsThe medical records of 885 children hospitalized with Flu A virus infection at a tertiary hospital in Guangdong Province, China, were retrospectively analyzed. Flu A was confirmed in these cases using a direct immunofluorescence antigen assay. The clinical data for this study span from January 1, 2018, to May 31, 2023.
resultsIn our study, we observed a total of 340 cases before the COVID-19 pandemic, 196 cases during the pandemic, and 349 cases after the pandemic. Patients after the pandemic had a higher median age on admission (5.66 years, range 3.41-7.70) and exhibited more respiratory symptoms such as cough, sore throat, and nasal stuffiness. The length of hospital stay was longer, and there was a higher percentage of patients with fever duration ≥ 5 days among Flu A patients during the pandemic. Compared to before and during the COVID-19 pandemic, Flu A patients after the pandemic showed significantly reduced white blood cell (WBC) and platelet (PLT) counts (P < 0.001), along with elevated levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in laboratory indexes (P < 0.001). Furthermore, more hospitalized children after the pandemic were diagnosed with benign acute childhood myositis (BACM).
conclusionOur research results indicates a significant decrease in Flu A cases during the COVID-19 pandemic, and hospitalized children with Flu A have more severe clinical symptoms after the COVID-19 pandemic. These findings have implications for public health policy and clinical management of Flu A cases. CLINICAL TRIAL NUMBER: Not applicable.
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