Evidence map›Paper›PMID 39702013›Full record

ArticleBMC cardiovascular disorders2024

Troponin-T as predictor of mortality in patients attending the emergency department with atrial fibrillation.

Serkan Celik, Linus Bodeström Eriksson, Jakob Hytting, Annette Waldemar, Panagiotis Mallios, Amanda Berggren, Ellen Oscarsson, Christofer Digerfeldt, Magnus Wijkman, Laila Hubbert

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In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Serkan CelikDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden. serkan.celik@regionostergotland.se.
Linus Bodeström ErikssonDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.
Jakob HyttingDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.
Annette WaldemarDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.
Panagiotis MalliosDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.
Amanda BerggrenDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.
Ellen OscarssonDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.
Christofer DigerfeldtDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.
Magnus WijkmanDepartment of Medicine and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, Sweden.
Laila HubbertDepartment of Cardiology and Department of Health, Medicine, and Caring Sciences, Linkoping University, Norrkoping, SE-601 82, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-sensitive Troponin-T (hsTnT) is often increased in acute illness and may be of prognostic importance in patients with atrial fibrillation (AF). The aim of this study was to analyse the characteristics and data of patients attending the emergency department (ED) with AF to determine whether age-adjusted hsTnT levels can predict mortality.

methodsThis retrospective, single centre, register-based cohort study included all patients ≥ 18 years attending the emergency department during 2018 and 2020 with a primary diagnosis at the ED of AF and sampled for hsTnT. Symptoms, comorbidities, lab results, and characteristics were registered. Patients were divided into groups based on hsTnT level (< 15, 15-50, and > 50 ng/L). PRIMARY OUTCOMES: 30-day and 1-year mortality.

resultsA total of 625 patients were included (median age 72, and 45% female). All-cause mortality was 2% at 30 days and 8% at 1-year. The hazard ratio (HR) for 30-day mortality was 4.17 (95% confidence interval (CI) 0.49-35.79, p = 0.192) for hsTnT 15-50 ng/L and 9.64 (95% CI 0.98-95.30, p = 0.053) for hsTnT > 50 ng/L compared to hsTnT < 15 ng/L when adjusted for age. The HR for 1-year mortality was 4.82 (95% CI 1.81-12.82, p = 0.002) for hsTnT 15-50 ng/L and 9.70 (95% CI 3.27-28.74, p < 0.001) for hsTnT > 50 ng/L compared to hsTnT < 15 ng/L when adjusted for age.

conclusionsElevated hsTnT levels increase the risk for 30-day and 1-year mortality independently of age. Both mild and major elevation of hsTnT levels is associated with increased risk for 1-year mortality regardless of age.

Indexed as

Atrial FibrillationBiomarkersEmergency Service, HospitalPredictive Value of TestsRegistriesTroponin TAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentRisk FactorsBiomarkersTroponin TAtrial fibrillationEmergency departmentMortalityTroponin-T

Identifiers

PMID39702013
PMCPMC11660876

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.