Evidence map›Paper›PMID 39702010›Full record

Trial reportBMC cardiovascular disorders2024

Blood flow dynamics in the ascending aorta of patients with bicuspid aortic valve before and after transcatheter aortic valve replacement: a computational fluid dynamics study.

Kang An, Fengwen Zhang, Wenbin Ouyang, Xiangbin Pan

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05739253 (Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05739253 recruitingnot on this map

Changes of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement

TypeobservationalSponsorChina National Center for Cardiovascular DiseasesRan2022 to 2025Enrolled480ConditionsAortic Stenosis, Ascending Aortic Dilatation, Bicuspid Aortic ValveArmsTranscatheter aortic valve replacement
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kang AnDepartment of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Fengwen ZhangDepartment of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Wenbin OuyangDepartment of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Xiangbin PanDepartment of Structural Heart Disease, National Center for Cardiovascular Disease, China & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. panxiangbin@fuwaihospital.org.

Funding

Beijing Municipal Science and Technology Project Z201100005420030CAMS Innovation Fund for Medical Sciences 2021-I2M-1-065National High Level Talents Special Support Plan 2020-RSW02National Natural Science Foundation of China 81970444Sanming Project of Medicine in Shenzhen SZSM202011013The Fundamental Research Funds for the Central Universities 2019PT350005
6 · The paper itself

Abstract

backgroundAbnormal blood flow patterns are known to contribute to the ascending aortic dilation in patients with bicuspid aortic valve (BAV). The present study elucidated the blood flow characteristics in the dilated ascending aorta before and after transcatheter aortic valve replacement (TAVR) using computational fluid dynamics (CFD) analysis.

methodsWe performed CFD analysis in three BAV patients with ascending aortic dilation (maximum diameter ≥ 45 mm) who underwent TAVR. The blood flow streamline was visualized to evaluate the pre- and post-operative flow velocity, severity of vortex and helix, and wall shear stress (WSS) in the ascending aorta.

resultsBefore the procedure, all three patients showed abnormal blood flow patterns, with vortex and helix in the ascending aorta. Regionally elevated WSS was also observed in the lateral or posterior ascending aortic wall (16.7 Pa, 12.2 Pa, and 14.5 Pa in patient 1, 2, and 3, respectively). After the procedure, the blood flow patterns significantly improved, and the maximum WSS also decreased (4.2 Pa, 1.1 Pa, and 3.2 Pa in patient 1, 2, and 3, respectively).

conclusionAbnormal blood flow patterns and WSS appeared to improve after TAVR in BAV patients with ascending aortic dilation. The impact on the long-term aortic growth rate and the incidence of aortic dissection requires further studies.

trial registrationChanges of Ascending Aortic Diameter in Patients Undergoing Transcatheter Aortic Valve Replacement. CLINICALTRIAL: gov number NCT05739253. Trial registration date 20,230,212.

Indexed as

AortaAortic ValveBicuspid Aortic Valve DiseaseHeart Valve DiseasesHemodynamicsHydrodynamicsModels, CardiovascularRegional Blood FlowTranscatheter Aortic Valve ReplacementAgedAged, 80 and overAortic AneurysmAortic Valve StenosisAortographyBlood Flow VelocityComputed Tomography AngiographyAscending aortic dilationBicuspid aortic valveComputational fluid dynamicsTranscatheter aortic valve replacement

Identifiers

PMID39702010
PMCPMC11660676

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.