Evidence map›Paper›PMID 39701963›Full record

SynthesisThe journal of headache and pain2024

Pain profiling in migraine: a systematic review of Quantitative Sensory Testing (QST), Conditioned Pain Modulation (CPM), and Corneal Confocal Microscopy (CCM).

Floor Clarissa van Welie, Albert Dahan, Monique van Velzen, Gisela Marie Terwindt

Registry-linked trialAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The journal of headache and pain, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07514208 (Pericranial and General Sensitivity in Patients With Primary Headache), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07514208 enrolling by invitationnot on this mapstarted 2026, after this paper: background citation

Pericranial and General Sensitivity in Patients With Primary Headache: a Multicenter Case-control Study

TypeobservationalSponsorUniversitat Internacional de CatalunyaRan2026 to 2027Enrolled120ConditionsPrimary Headache Disorders, Tension Headache, Tension-type Headache, MigraineArmsPericranial Tenderness Assessment, Pressure Pain Threshold Assessment, Temporomandibular Disorder Assessment, Patient-Reported Outcome Assessment, Cervical Function Assessment
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline
  2. Observational
  3. Review
  4. Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Floor Clarissa van WelieDepartment of Neurology, Leiden University Medical Center, P.O. 9600, Leiden, 2300 WB, The Netherlands.
Albert DahanDepartment of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Monique van VelzenDepartment of Anesthesiology, Leiden University Medical Center, Leiden, The Netherlands.
Gisela Marie TerwindtDepartment of Neurology, Leiden University Medical Center, P.O. 9600, Leiden, 2300 WB, The Netherlands. G.M.Terwindt@lumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of this systematic review is to identify pain profiling parameters that are reliably different between patients with migraine and healthy controls, using Quantitative Sensory Testing (QST) including Temporal Summation (TS), Conditioned Pain Modulation (CPM), and Corneal Confocal Microscopy (CCM).

methodsA comprehensive literature search was conducted (up to 23 May 2024). The quality of the research was assessed using the Newcastle-Ottawa Scale (NOS) for non-randomized studies.

resultsTwenty-eight studies were included after screening. The QST studies indicate that migraine patients exhibit lower pressure pain thresholds (PPT), particularly in the trigeminal region. A previous meta-analysis reported lower heat pain thresholds (HPT). CPM studies suggest a (mild) inhibitory or absent response in migraine patients, not different from controls. High-frequency and chronic migraine patients may exhibit a facilitatory CPM response. With repeated executions of CPM, migraine patients display a diminishing CPM response, a phenomenon not observed in control subjects. CCM investigations in migraine patients revealed conflicting outcomes, likely as a result of small sample sizes and limited characterization of migraine features.

conclusionPain profiling migraine patients varies due to sensory modality, applied methods, anatomical sites, and migraine features. Understanding pain profiling offers insights into migraine pathophysiology, requiring careful selection of parameters and differentiation among migraine subtypes.

Indexed as

CorneaMicroscopy, ConfocalMigraine DisordersPain MeasurementPain ThresholdHumansAllodyniaChronic migraine (CM)Conditioned Pain Modulation (CPM)Corneal Confocal Microscopy (CCM)Episodic migraine (EM)MigrainePain profilePsychophysical measureQuantitative Sensory Testing (QST)

Identifiers

PMID39701963
PMCPMC11660458

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.