ArticleCell reports methods2025
A core genome MLST scheme for Borrelia burgdorferi sensu lato improves insights into the evolutionary history of the species complex.
Article in Cell reports methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Fast and efficient Borrelia chromosome recovery from tick samples using whole-genome amplification.Cell reports methods · 2026Article
- Reply to the letter regarding 'Unravelling the genomic landscape of CanadianMicrobial genomics · 2026Article
- The wild, wild west of plasmids: First insights into comparative genomics of Borrelia burgdorferi sensu lato.PloS one · 2026Article
- Borreliosis and Other Tick-Borne Diseases in the Northern and Southern Hemispheres.Microorganisms · 2025Article
- Borrelial Diseases Across Eurasia.Biology · 2025Review
- Detection of Borrelia burgdorferi (s.l.) in Ixodes ricinus ticks collected in Iceland.Parasites & vectors · 2025Article
- Comparative genomic analysis of food-animal-derived and human-derivedFrontiers in microbiology · 2025Article
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10 authors.
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Abstract
Multi-locus sequence typing (MLST) based on eight genes has become the method of choice for Borrelia typing and is extensively used for population studies. Whole-genome sequencing enables studies to scale up to genomic levels but necessitates extended schemes. We have developed a 639-loci core genome MLST (cgMLST) scheme for Borrelia burgdorferi sensu lato (s.l.) that enables unambiguous genotyping and improves the robustness of phylogenies and lineage resolution within species. Notably, all inner nodes of the cgMLST phylogenies had consistently high statistical support. Analyses of the genetically homogeneous European B. bavariensis population support the notion that cgMLST provides high discriminatory power even for closely related isolates. While isolates differed maximally in one MLST locus, there were up to 179 cgMLST loci differences. Thus, the developed cgMLST scheme for B. burgdorferi s.l. resolves lineages at a finer resolution than MLST and improves insights into the evolutionary history of the species complex.
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