Evidence map›Paper›PMID 39700596›Full record

ArticleCarbohydrate research2025

Sialylation reactions: Expanding the C-5 effect to phosphate leaving groups.

Anupama Das, Shay Adio, Jeremy Brincken, Alexei V Demchenko, Cristina De Meo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Carbohydrate research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anupama DasDepartment of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, MO, 63103, USA.
Shay AdioDepartment of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA.
Jeremy BrinckenDepartment of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA.
Alexei V DemchenkoDepartment of Chemistry, Saint Louis University, 3501 Laclede Ave, St. Louis, MO, 63103, USA.
Cristina De MeoDepartment of Chemistry, Southern Illinois University Edwardsville, Edwardsville, IL, 62026, USA. Electronic address: cdemeo@siue.edu.

Funding

Methods and technologies for chemical synthesis of glycansR35GM152125 · NIGMS · SAINT LOUIS UNIVERSITY · PI ALEXEI V DEMCHENKO · 2024 to 2026
$1.2M
NIGMS NIH HHS R35 GM152125
6 · The paper itself

Abstract

With the expanding use of phosphates as leaving groups in sialylations, little remains known about the C-5 effect towards their reactivity and stereoselectivity in the presence of a range of acceptors, and in different solvents. Herein we report the comparison between sialyl phosphate donors bearing N-acetyloxazolidinone and trifluoroacetamido functionalities at C-5. Excellent results and complete stereoselectivity were observed in several sialylations, but the outcome was influenced by the nature of the solvent and/or glycosyl acceptor.

Indexed as

PhosphatesGlycosylationStereoisomerismPhosphatesLeaving groupsO-glycosylationPhosphateSialic acid

Identifiers

PMID39700596
PMCPMC11921016

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.