Evidence map›Paper›PMID 39700441›Full record

ArticleJCO oncology practice2025

Implementation of Universal Germline Genetic Testing Into Standard of Care for Patients With Prostate Cancer: The Time Is Now.

Neal Shore, Sarah M Nielsen, Edward D Esplin, Emmanuel S Antonarakis, Pedro C Barata, Tomasz M Beer, Himisha Beltran, Alan Bryce, Michael S Cookson, E David Crawford and 16 more

Abstract read
In one paragraph

Article in JCO oncology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Neal ShoreCarolina Urologic Research Center, Myrtle Beach, SC.ORCID 0000-0001-5767-0548
Sarah M NielsenLabcorp Genetics Inc (formerly Invitae Corp), San Francisco, CA.ORCID 0000-0002-5916-6393
Edward D EsplinLabcorp Genetics Inc (formerly Invitae Corp), San Francisco, CA.ORCID 0000-0001-9205-3756
Emmanuel S AntonarakisUniversity of Minnesota, Masonic Cancer Center, Minneapolis, MN.ORCID 0000-0003-0031-9655
Pedro C BarataCase Western Reserve University, Cleveland, OH.ORCID 0000-0002-8890-2951
Tomasz M BeerThe Knight Cancer Institute, Oregon Health & Science University, Portland, OR.ORCID 0000-0001-5600-9993
Himisha BeltranDana Faber Cancer Institute, Boston, MA.ORCID 0000-0003-3259-2226
Alan BryceCity of Hope Cancer Center, Goodyear, AZ.ORCID 0000-0002-0206-3895
Michael S CooksonStephenson Cancer Center, OU Health, The University of Oklahoma, Oklahoma City, OK.
E David CrawfordUniversity California, San Diego, La Jolla, CA.
Tanya B DorffCity of Hope Cancer Center, Goodyear, AZ.ORCID 0000-0001-5990-298X
Daniel J GeorgeDuke Cancer Institute, Duke University, Durham, NC.ORCID 0000-0003-1499-7203
Elisabeth I HeathKarmanos Cancer Institute, Detroit, MI.ORCID 0000-0003-1381-2713
Brian T HelfandNorthShore University HealthSystem/Endeavor Health, Evanston, IL.ORCID 0000-0002-7707-3318
Maha HussainNorthwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0003-0380-9465
Rana R MckayUniversity California, San Diego, La Jolla, CA.ORCID 0000-0002-0581-7963
Alicia K MorgansDana Faber Cancer Institute, Boston, MA.ORCID 0000-0002-6563-4587
Michael J MorrisMemorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-9454-0096
Channing J PallerThe Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD.
Ashley E RossNorthwestern Feinberg School of Medicine, Chicago, IL.ORCID 0000-0001-7044-9688
Oliver SartorMayo Clinic, Rochester, MN.ORCID 0000-0002-8777-7343
John ShenUCLA David Geffen School of Medicine, Los Angeles, CA.
Paul SieberKeystone Urology Specialists, Lancaster, PA.
Matthew R SmithMassachusetts General Hospital, Boston, MA.
David R WisePerlmutter Cancer Center, NYU Langone Health, New York, NY.ORCID 0000-0003-3419-4723
Andrew J ArmstrongDuke Cancer Institute, Duke University, Durham, NC.ORCID 0000-0001-7012-1754

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Molecular mechanisms underlying lineage plasticity in prostate cancerR37CA241486 · NCI · DANA-FARBER CANCER INST · PI Himisha Beltran · 2020 to 2026
$4.1M
NCI NIH HHS P30 CA008748NCI NIH HHS R37 CA241486
6 · The paper itself

Abstract

Indications for and implications of germline genetic testing (GGT) in patients with prostate cancer have expanded over the past decade, particularly related to precision therapies and management. GGT has become the standard of care for many cancers such as breast, ovarian, colorectal, pancreatic, and metastatic prostate cancer, and it is imperative that patients be offered timely and equitable access to testing as it can inform patient-physician shared decision making for management of the current cancer as well as anticipatory guidance for disease progression. Additionally, GGT guides screening for and prevention of secondary malignancies for the patient and cascade testing for at-risk family members. Here, we present data supporting the notion that clinicians should offer all patients with prostate cancer the opportunity to undergo comprehensive GGT for pathogenic germline variants known to be associated with familial cancer and/or known to have implications for treatment and management.

Indexed as

Genetic TestingGerm-Line MutationProstatic NeoplasmsStandard of CareHumansMale

Identifiers

PMID39700441
PMCPMC12162241

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.