Evidence map›Paper›PMID 39700339›Full record

ArticleJournal of medicinal chemistry2025

Identification of Novel Human 15-Lipoxygenase-2 (h15-LOX-2) Inhibitors Using a Virtual Screening Approach.

Lucas G Viviani, Thais S Iijima, Erika Piccirillo, Leandro Rezende, Thiago G P Alegria, Luis Eduardo S Netto, Antonia T-do Amaral, Sayuri Miyamoto

Abstract read
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In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas G VivianiDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil.ORCID 0000-0002-4767-4825
Thais S IijimaDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil.ORCID 0009-0002-6742-0846
Erika PiccirilloCenter for Medicinal Chemistry (CQMED), State University of Campinas, Av. André Tosello 550, 13083-886 Campinas, Brazil.
Leandro RezendeDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil.
Thiago G P AlegriaDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, Rua do Matão, 277, 05508-090 São Paulo, Brazil.ORCID 0000-0002-3086-4059
Luis Eduardo S NettoDepartment of Genetics and Evolutionary Biology, Institute of Biosciences, University of São Paulo, Rua do Matão, 277, 05508-090 São Paulo, Brazil.ORCID 0000-0002-4250-9177
Antonia T-do AmaralDepartment of Fundamental Chemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil.ORCID 0000-0003-2937-5255
Sayuri MiyamotoDepartment of Biochemistry, Institute of Chemistry, University of São Paulo, Av. Prof. Lineu Prestes 748, 05508-000 São Paulo, Brazil.ORCID 0000-0002-5714-8984

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human 15-lipoxygenase-2 (h15-LOX-2) catalyzes mainly the regio- and stereospecific oxygenation of arachidonate to its corresponding hydroperoxide (15(

Indexed as

Arachidonate 15-LipoxygenaseLipoxygenase InhibitorsMolecular Docking SimulationDrug Evaluation, PreclinicalHumansStructure-Activity RelationshipArachidonate 15-LipoxygenaseLipoxygenase Inhibitors

Identifiers

PMID39700339
PMCPMC11726667

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.