Evidence map›Paper›PMID 39700271›Full record

ArticleScience (New York, N.Y.)2024

Biocatalytic C-H oxidation meets radical cross-coupling: Simplifying complex piperidine synthesis.

Jiayan He, Kenta Yokoi, Breanna Wixted, Benxiang Zhang, Yu Kawamata, Hans Renata, Phil S Baran

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026
    Review
  6. Article
  7. Conformation-driven C3-C(Nature catalysis · 2026
    Article
  8. Selective P450Organic letters · 2025
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiayan He *Department of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, USA.ORCID 0009-0004-3541-3945
Kenta Yokoi *Department of Chemistry, BioScience Research Collaborative, Rice University, Houston, TX, USA.ORCID 0000-0002-3437-4567
Breanna WixtedDepartment of Chemistry, BioScience Research Collaborative, Rice University, Houston, TX, USA.ORCID 0009-0003-4377-8568
Benxiang ZhangDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, USA.ORCID 0009-0009-6787-2288
Yu KawamataDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, USA.ORCID 0000-0002-5515-9612
Hans RenataDepartment of Chemistry, BioScience Research Collaborative, Rice University, Houston, TX, USA.ORCID 0000-0003-2468-2328
Phil S BaranDepartment of Chemistry, Scripps Research, 10550 North Torrey Pines Road, La Jolla, CA, USA.ORCID 0000-0001-9193-9053

Funding

Scalable Synthesis and New Bond DisconnectionsR35GM118176 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI BARAN, PHIL S · 2016 to 2025
$11.5M
Biocatalytic C-H Functionalization Logic in the Chemoenzymatic Synthesis of Therapeutic Natural ProductsR35GM128895 · NIGMS · UNIVERSITY OF FLORIDA · PI Hans Renata · 2018 to 2026
$3.7M
NIGMS NIH HHS R35 GM118176NIGMS NIH HHS R35 GM128895
6 · The paper itself

Abstract

Modern medicinal chemists are targeting more complex molecules to address challenging biological targets, which leads to synthesizing structures with higher sp

Identifiers

PMID39700271
PMCPMC11760214

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.