Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Mariana R Tavares *Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0001-6317-6853
Willian O Dos Santos *Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0002-8270-5375
Andressa G AmaralDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0002-1261-2982
Edward O ListEdison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701.ORCID 0000-0002-8230-6331
John J KopchickEdison Biotechnology Institute and Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701.
Guilherme A AlvesDepartment of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil.
Renata FrazaoDepartment of Anatomy, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-900, Brazil.
Jessica D M Dos SantosDepartment of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil.ORCID 0000-0002-7950-3617
Alessandra G CruzDepartment of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil.ORCID 0000-0002-6280-5969
João Paulo CamporezDepartment of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, Brazil.ORCID 0000-0003-3486-4301
Jose DonatoDepartment of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo 05508-000, Brazil.ORCID 0000-0002-4166-7608
Funding
Modulating Growth Hormone Action as a Target for Improved Health and LongevityR01AG059779 · NIA · OHIO UNIVERSITY ATHENS · PI John Joseph Kopchick · 2018 to 2026
$4.7M
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 306024/2023-3Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 313752/2023-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2018/04956-5Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2020/01318-8Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2020/10102-9Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2021/08792-0Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2022/11262-5HHS | NIH (NIH) R01AG059779NIA NIH HHS R01 AG059779
6 · The paper itself
Abstract
Growth hormone (GH) has several metabolic effects, including a profound impact on glucose homeostasis. For example, GH oversecretion induces insulin resistance and increases the risk of developing diabetes mellitus. Here, we show that GH receptor (GHR) ablation in vesicular glutamate transporter 2 (VGLUT2)-expressing cells, which comprise a subgroup of glutamatergic neurons, led to a slight decrease in lean body mass without inducing changes in body adiposity. VGLUT2
Indexed as
Basic Helix-Loop-Helix ProteinsBlood GlucoseInsulin ResistanceReceptors, SomatotropinVesicular Glutamate Transport Protein 2AnimalsGlucoseGrowth HormoneLiverMaleMiceMice, Inbred C57BLNeuronsBasic Helix-Loop-Helix ProteinsBlood GlucoseGlucoseGrowth HormoneReceptors, SomatotropinSlc17a6 protein, mouseVesicular Glutamate Transport Protein 2diabetes mellitusGHglucose metabolisminsulin
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Growth hormone receptor in VGLUT2 or Sim1 cells regulates glycemia and insulin sensitivity. · full record | OpenQuestion