ArticleProceedings of the National Academy of Sciences of the United States of America2024
NPR1 promotes blue light-induced plant photomorphogenesis by ubiquitinating and degrading PIF4.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Phytochrome B integrates jasmonic acid and warm temperature signaling pathways to regulate cotyledon chloroplast development.Nature communications · 2026Article
- ZOMES: expanding roles of the PCI complexes from protein metabolism to drug discovery.npj metabolic health and disease · 2026Article
- Salicylic acid and ROS signaling modulate hypocotyl elongation in darkness via NPR1 and EX1.Science advances · 2025Article
- Living with temperature changes: Salicylic acid at the crossroads of plant immunity and temperature resilience.Science advances · 2025Review
- A Comprehensive Review of Phenolic Compounds in Horticultural Plants.International journal of molecular sciences · 2025Review
- NPR1 promotes blue light-induced plant photomorphogenesis by ubiquitinating and degrading PIF4.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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Authors and funding
13 authors.
Funding
Abstract
Light is a major determinant of plant growth and survival. NONEXPRESSER OF PATHOGENESIS-RELATED GENES 1 (NPR1) acts as a receptor for salicylic acid (SA) and serves as the key regulator of SA-mediated immune responses. However, the mechanisms by which plants integrate light and SA signals in response to environmental changes, as well as the role of NPR1 in regulating plant photomorphogenesis, remain poorly understood. This study shows that SA promotes plant photomorphogenesis by regulating PHYTOCHROME INTERACTING FACTOR 4 (PIF4). Specifically, NPR1 promotes photomorphogenesis under blue light by facilitating the degradation of PIF4 through light-induced polyubiquitination. NPR1 acts as a substrate adaptor for the CULLIN3-based E3 ligase, which ubiquitinates PIF4 at Lys129, Lys252, and Lys428, and leading to PIF4 degradation via the 26S proteasome pathway. Genetically,
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Registered trials
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