ArticlePloS one2024
Use of vasopressors in patients with acute kidney injury on continuous kidney replacement therapy.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- A machine learning model for predicting 28-day mortality in ICU patients with community-acquired pneumonia and acute kidney injury.Scientific reports · 2025Article
- Perioperative approach to nephrotoxicity in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.World journal of gastrointestinal surgery · 2025Article
- Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study.PloS one · 2025Observational
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo investigate whether the use of a specific vasopressor was associated with increased mortality or adverse outcomes in patients with acute kidney injury (AKI) receiving continuous kidney replacement therapy (CKRT).
methodsPatients with AKI who underwent CKRT between 1/1/2012-1/1/2021 at a tertiary academic hospital were included. Cox proportional hazard model was used to assess the relationship between time-dependent vasopressor dose and in-hospital mortality.
resultsThere were 641 patients with AKI that required CKRT. In-hospital mortality occurred in 318 (49.6%) patients. Those who died were older (63 vs 57 years), had higher SOFA score (10.6 vs 9) and lactate (6 vs 3.3 mmol/L). In multivariable model, increasing doses of norepinephrine [HR 4.4 (95% CI: 2.3-7, p<0.001)] per 0.02 mcg/min/kg and vasopressin [HR 2.6 (95% CI: 1.9-3.2, p = 0.01)] per 0.02 unit/min during CKRT were associated with in-hospital mortality. The model was adjusted for vasopressor doses and fluid balance, SOFA score, lactate and other markers of severity of illness. Baseline vasopressor doses were not associated with mortality. Most vasopressors were associated with positive daily fluid balance. Among survivors at day 30, mean values of vasopressors were not associated with persistent kidney dysfunction.
conclusionThe associations between norepinephrine and vasopressin with in-hospital mortality could be related to their common use in this cohort.
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