Evidence map›Paper›PMID 39699995›Full record

ArticleDiabetes care2025

Limitations in Achieving Glycemic Targets From CGM Data and Persistence of Severe Hypoglycemia in Adults With Type 1 Diabetes Regardless of Insulin Delivery Method.

Lori M Laffel, Jennifer L Sherr, Jingwen Liu, Wendy A Wolf, Jeoffrey Bispham, Katherine S Chapman, Daniel Finan, Lina Titievsky, Tina Liu, Kaitlin Hagan and 4 more

Abstract read
In one paragraph

Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Observational
  5. Review
  6. Review
  7. Article
  8. Article
  9. Moving the Goalposts: Do Adults With Type 1 Diabetes Want Time in Tight Range?Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lori M LaffelJoslin Diabetes Center, Harvard Medical School, Boston, MA.
Jennifer L SherrYale School of Medicine, New Haven, CT.
Jingwen LiuT1D Exchange, Boston, MA.
Wendy A WolfT1D Exchange, Boston, MA.
Jeoffrey BisphamT1D Exchange, Boston, MA.
Katherine S ChapmanT1D Exchange, Boston, MA.
Daniel FinanT1D Exchange, Boston, MA.
Lina TitievskyVertex Pharmaceuticals, Boston, MA.
Tina LiuVertex Pharmaceuticals, Boston, MA.
Kaitlin HaganVertex Pharmaceuticals, Boston, MA.
Jason GagliaJoslin Diabetes Center, Harvard Medical School, Boston, MA.
Keval ChandaranaVertex Pharmaceuticals, Boston, MA.
Jeremy PettusUniversity of California, San Diego, La Jolla, CA.
Richard BergenstalInternational Diabetes Center, HealthPartners Institute, Minneapolis, MN.ORCID 0000-0002-9050-5584

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P30 DK036836Vertex Pharmaceuticals Incorporated
6 · The paper itself

Abstract

objectiveWe captured continuous glucose monitoring (CGM) metrics from a large online survey of adults with type 1 diabetes to determine how glycemic outcomes varied by insulin delivery form. RESEARCH DESIGN AND

methodsAdults with type 1 diabetes from the T1D Exchange Registry/online communities completed the survey and contributed retrospective CGM data for up to 1 year. Self-reported glycemic outcomes and CGM measures were described overall and by insulin delivery method.

resultsThe 926 participants completed the survey and provided CGM data. Mean ± SD age was 41.9 ± 15.7 years, and 50.8% reported using automated insulin delivery (AID). While AID users spent more time in range, 27.9% did not achieve time in range targets, 15.5% reported severe hypoglycemic events (SHEs), and 16.0% had CGM-detected level 2 hypoglycemic events.

conclusionsDespite use of diabetes technologies, many individuals are unable to achieve glycemic targets and experience severe hypoglycemia, highlighting the need for novel treatments.

Indexed as

Blood GlucoseDiabetes Mellitus, Type 1HypoglycemiaHypoglycemic AgentsInsulinAdultBlood Glucose Self-MonitoringFemaleHumansInsulin Infusion SystemsMaleMiddle AgedRetrospective StudiesBlood GlucoseHypoglycemic AgentsInsulin

Identifiers

PMID39699995
PMCPMC11770157

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.