Evidence map›Paper›PMID 39699988›Full record

SynthesisDental press journal of orthodontics2024

Changes in salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment: a systematic review.

Rodrigo Rodrigues, Caio Melo Mesquita, Helena Benatt do Nascimento Alves, Filipe Gontijo Silva, Walbert de Andrade Vieira, Paula Cristiana Santos de Aguiar, Carlos Flores-Mir, Luiz Renato Paranhos, Rui Barbosa de Brito-Júnior

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Dental press journal of orthodontics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rodrigo RodriguesSão Leopoldo Mandic College, Dentistry Course (Campinas/SP, Brazil).ORCID http://orcid.org/0000-0002-4218-2303
Caio Melo MesquitaFederal University of Uberlândia, Dentistry Course (Uberlândia/MG, Brazil).ORCID http://orcid.org/0000-0002-6892-3659
Helena Benatt do Nascimento AlvesFederal University of Uberlândia, Dentistry Course (Uberlândia/MG, Brazil).ORCID http://orcid.org/0000-0003-3895-7871
Filipe Gontijo SilvaFederal University of Uberlândia, Dentistry Course (Uberlândia/MG, Brazil).ORCID http://orcid.org/0009-0000-6816-7315
Walbert de Andrade VieiraState University of Campinas, Dentistry Course, Endodontics Department (Campinas/SP, Brazil).ORCID http://orcid.org/0000-0001-8872-2865
Paula Cristiana Santos de AguiarSão Leopoldo Mandic College, Dentistry Course (Campinas/SP, Brazil).ORCID http://orcid.org/0000-0003-3226-3916
Carlos Flores-MirUniversity of Alberta, School of Medicine and Dentistry, Department of Dentistry (Edmonton, Canada).ORCID http://orcid.org/0000-0002-0887-9385
Luiz Renato ParanhosFederal University of Uberlândia, Dentistry Course, Department of Preventive and Social Dentistry (Uberlândia/MG, Brazil).ORCID http://orcid.org/0000-0002-7599-0120
Rui Barbosa de Brito-JúniorSão Leopoldo Mandic School of Dentistry, Department of Molecular Biology (Campinas/SP, Brazil).ORCID http://orcid.org/0000-0002-3484-9438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis systematic review aimed to analyze the literature on changes in endogenous salivary biomarkers of pain, anxiety, stress, and inflammation related to tooth movement during orthodontic treatment of children and adolescents. MATERIAL AND

methodsAn electronic search was performed in nine databases to identify quasi-experimental studies, without restricting publication language and year. Two reviewers extracted the data and assessed the individual risk of bias using the JBI tools, and the certainty of evidence using the GRADE tool.

resultsThe electronic search found 7,038 records, of which 12 met the eligibility criteria and were included in the qualitative synthesis. Most studies had a low risk of bias. Biomarkers were grouped into five categories: electrolytes, enzymes, hormones, immunoglobulins, and mediators. Electrolytes showed decreased Ca2+, Pi3+ and K+ levels, and increased Na+ and Cl- levels. All enzymes (ALP, LDH, MMP8, and MMP9) increased over time. Hormones presented a decrease in leptin and some fluctuations in daily cortisol levels. Immunoglobulins (IgA, IgG, IgM, IgD, and IgE) had no significant changes, and salivary IgA showed divergent results among studies. Mediators (sRANKL, OPG, IL-1β, and PGE2) showed fluctuations at different treatment stages, mainly after orthodontic activation.

conclusionsBased on a very low certainty level, orthodontic tooth movement had little to no effect on endogenous salivary biomarkers.

Indexed as

BiomarkersInflammationSalivaTooth Movement TechniquesAdolescentAnxietyChildHumansHydrocortisoneMatrix Metalloproteinase 8PainStress, PsychologicalBiomarkersHydrocortisoneMatrix Metalloproteinase 8

Identifiers

PMID39699988
PMCPMC11655016

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.