Evidence map›Paper›PMID 39699945›Full record

ArticleeLife2024

The geometric basis of epithelial convergent extension.

Fridtjof Brauns, Nikolas H Claussen, Matthew F Lefebvre, Eric F Wieschaus, Boris I Shraiman

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. The role of geometry in morphogenesis.Development (Cambridge, England) · 2026
    Review
  2. Article
  3. Article
  4. bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025
    Article
  10. A model for boundary-driven tissue morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. A geometric-tension-dynamics model of epithelial convergent extension.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Fridtjof Brauns *Kavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, United States.ORCID https://orcid.org/0000-0002-6108-9278
Nikolas H Claussen *Department of Physics, University of California, Santa Barbara, Santa Barbara, United States.ORCID https://orcid.org/0000-0002-9020-6437
Matthew F LefebvreDepartment of Physics, University of California, Santa Barbara, Santa Barbara, United States.ORCID https://orcid.org/0000-0002-9590-4293
Eric F WieschausDepartment of Molecular Biology, Princeton University, Princeton, United States.ORCID https://orcid.org/0000-0002-0727-3349
Boris I ShraimanKavli Institute for Theoretical Physics, University of California, Santa Barbara, Santa Barbara, United States.ORCID https://orcid.org/0000-0003-0886-8990

Funding

Physics of Living Matter: From Molecule to Embryo.R35GM138203 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Sebastian J Streichan · 2020 to 2026
$2.7M
Gordon and Betty Moore Foundation 2919National Science Foundation PHY-2047140National Science Foundation PHY:2210612NIGMS NIH HHS R35 GM138203NIGMS NIH HHS R35-GM138208
6 · The paper itself

Abstract

Shape changes of epithelia during animal development, such as convergent extension, are achieved through the concerted mechanical activity of individual cells. While much is known about the corresponding large-scale tissue flow and its genetic drivers, fundamental questions regarding local control of contractile activity on the cellular scale and its embryo-scale coordination remain open. To address these questions, we develop a quantitative, model-based analysis framework to relate cell geometry to local tension in recently obtained time-lapse imaging data of gastrulating

Indexed as

Drosophila melanogasterAnimalsCell ShapeDrosophilaEmbryo, NonmammalianEpithelial CellsEpitheliumGastrulationModels, BiologicalMorphogenesisTime-Lapse Imagingactive cell intercalationconvergent extensiondevelopmental biologyD. melanogasterpassive cell intercalationphysics of living systemsself-organizationtissue mechanics

Identifiers

PMID39699945
PMCPMC11658770

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.