Evidence map›Paper›PMID 39699645›Full record

ArticleNeuroradiology2025

Dynamic susceptibility contrast perfusion MRI helps in differentiating double-expressor from non-double-expressor subtypes in primary central nervous system lymphoma.

Goh Sasaki, Hiroyuki Uetani, Jun-Ichiro Kuroda, Mika Kitajima, Soichiro Ishiuchi, Kanako Sato, Yi Wang, Akitake Mukasa, Toshinori Hirai

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Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Goh SasakiDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0009-0007-7443-2585
Hiroyuki UetaniDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. hama-moto@hotmail.co.jp.ORCID http://orcid.org/0000-0002-0547-1210
Jun-Ichiro KurodaDepartment of Neurosurgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0003-3912-4054
Mika KitajimaDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0002-6869-3638
Soichiro IshiuchiDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Kanako SatoDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Yi WangDepartment of Radiology, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-1404-8526
Akitake MukasaDepartment of Neurosurgery, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0001-7776-9086
Toshinori HiraiDepartment of Diagnostic Radiology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID http://orcid.org/0000-0003-1480-2197

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn the 2016 WHO Classification of Lymphoid Tissue Neoplasms, co-expression of MYC and BCL2 is newly designated as double expressor lymphoma. Patients with primary central nervous system lymphoma with double expressor (DE-PCNSL) have been reported to have a higher risk of recurrence and a worse prognosis than those with PCNSL without double expressor (non-DE-PCNSL). The aim of this study was to determine whether DE-PCNSL has characteristic clinical and MR imaging features compared to non-DE-PCNSL.

methodsThis study included 36 immunocompetent patients with PCNSL, including 16 with double expressor and 20 without double expressor. The enhancement pattern and the values of apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), leakage-corrected rCBV, and K2 at enhancing lesions were compared between the DE-PCNSL and non-DE-PCNSL groups. The mean and minimum values from the ROI on ADC maps were designated as ADC

resultsDE-PCNSL was significantly more common in women (12 of 16 patients, 75%) compared to non-DE-PCNSL (7 of 20 patients, 35%; P =.02). The rCBV ratio and leakage-corrected rCBV ratio were significantly lower in DE-PCNSL compared to non-DE-PCNSL (P =.02 and P =.03, respectively). There was no significant difference in the enhancement pattern and ADC

conclusionrCBV and leakage-corrected rCBV may help differentiate double-expressor from non-double-expressor subtypes in PCNSL.

Indexed as

Central Nervous System NeoplasmsLymphomaMagnetic Resonance AngiographyMagnetic Resonance ImagingAdultAgedContrast MediaDiagnosis, DifferentialFemaleHumansMaleMiddle AgedPerfusion Magnetic Resonance ImagingRetrospective StudiesContrast MediaADCDouble-expressor lymphomaPCNSLrCBV

Identifiers

PMID39699645

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.