Evidence map›Paper›PMID 39699591›Full record

ArticleBiomolecules & biomedicine2025

The association of rs25487 of the

Tatiana Zavarykina, Maria Kapralova, Polina Lomskova, Aleksandra Asaturova, Grigory Khabas, Lyailya Kayumova, Dmitry Khodyrev, Irina Pronina, Maya Sannikova, Svetlana Khokhlova

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Article in Biomolecules & biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Tatiana ZavarykinaN.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia; "B.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia.
Maria KapralovaN.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia.
Polina LomskovaN.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia.
Aleksandra Asaturova"B.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia.
Grigory Khabas"B.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia.
Lyailya KayumovaSechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Dmitry KhodyrevFederal Scientific and Clinical Center of Specialized Types of Medical Care and Medical Technologies, Federal Medical and Biological Agency of the Russian Federation, Moscow, Russia.
Irina ProninaN.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, Moscow, Russia; Institute of General Pathology and Pathophysiology, Moscow, Russia.
Maya Sannikova"B.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia; Yaroslav-the-Wise Novgorod State University, Novgorod, Russia.
Svetlana Khokhlova"B.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology", Ministry of Health of the Russian Federation, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer (OC) is the most lethal gynecological cancer worldwide. DNA damage plays an important role in cancer development, and the proteins encoded by XRCC1 and ERCC2 are important components of the DNA repair system. This study aimed to examine the relationship between the rs25487 XRCC1 and rs13181 ERCC2 polymorphisms and the risk of OC development in women from the Moscow region. DNA was isolated from the blood of 129 healthy donors and tissues and blood samples from 125 patients with OC and studied using real-time PCR. An increase in odds ratios (OR) was obtained for OC tissue and blood for both T (OR = 1.46, 95% confidence interval [CI] = 1.22-1.76, P = 0.00005), and for T/T of rs25487 XRCC1. The most significant OR values were found for the T/T genotype using the codominant model (OR = 2.11, 95% CI = 1.44-3.07, P = 0.00006) and dominant model (OR = 3.13, 95% CI = 1.44-6.79, P = 0.0025) for the pooled blood and tissue groups. For rs13181 ERCC2, differences were observed for the T/G genotype in OC tissues (OR = 0.69, 95% CI = 0.51-0.92, P = 0.011) in the codominant model. In this study, the association of allele T and genotypes of rs25487 XRCC1 and T/G of rs13181 ERCC2 with OC was shown. Our results indicate that these polymorphisms may be involved in the pathogenesis of OC and are promising for further studies on therapeutic applications in OC.

Indexed as

Genetic Predisposition to DiseaseOvarian NeoplasmsPolymorphism, Single NucleotideXeroderma Pigmentosum Group D ProteinX-ray Repair Cross Complementing Protein 1AdultAgedCase-Control StudiesFemaleGenotypeHumansMiddle AgedRisk FactorsERCC2 protein, humanXeroderma Pigmentosum Group D ProteinX-ray Repair Cross Complementing Protein 1XRCC1 protein, human

Identifiers

PMID39699591
PMCPMC11984361

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