Evidence map›Paper›PMID 39699427›Full record

ArticleRevista do Instituto de Medicina Tropical de Sao Paulo2024

Scrotal abscess caused by Candida glabrata in a patient with uncontrolled diabetes mellitus and chronic renal failure.

Mehmet Ali Tüz, Derya Tuna Ecer, Tuğba Kula Atik, Oktay Yapıcı

Abstract readCase Reports
In one paragraph

Article in Revista do Instituto de Medicina Tropical de Sao Paulo, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mehmet Ali TüzBalikesir University, Medical Faculty, Infectious Diseases and Clinical Microbiology Department, Balikesir, Turkey.ORCID http://orcid.org/0000-0002-9676-7681
Derya Tuna EcerBalikesir University, Medical Faculty, Infectious Diseases and Clinical Microbiology Department, Balikesir, Turkey.ORCID http://orcid.org/0009-0000-7020-2626
Tuğba Kula AtikBalikesir University, Medical Faculty, Medical Microbiology Department Balikesir, Turkey.ORCID http://orcid.org/0000-0002-2433-1977
Oktay YapıcıBalikesir University, Medical Faculty, Infectious Diseases and Clinical Microbiology Department, Balikesir, Turkey.ORCID http://orcid.org/0000-0002-5472-9919

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Candida glabrata is a yeast which incidence has increased in recent years and usually causes urogenital and bloodstream infections. Its resistance to fluconazole hinders C. glabrata infections treatment. This case report presents a case of candidemia and scrotal abscess caused by C. glabrata, which was successfully treated with liposomal amphotericin B. The primary treatment options for C. glabrata candidemia are echinocandins and amphotericin B formulations. However, echinocandins and lipid-based amphotericin B formulations do not properly pass through the urinary system. Amphotericin B deoxycholate has a high risk of side effects and is difficult to obtain. The treatment option for candidemia caused by fluconazole-resistant C. glabrata secondary to urinary tract infection is unclear and there are no sufficient studies. For treatment, liposomal amphotericin B may be considered, especially for scrotal and prostatic fluconazole-resistant fungal abscesses. More studies comparing the penetration of antifungals into scrotal and prostatic tissue and the success of antifungal treatment in these tissue infections are needed.

Indexed as

AbscessAntifungal AgentsCandida glabrataKidney Failure, ChronicScrotumAgedAmphotericin BCandidemiaCandidiasisGenital Diseases, MaleHumansMaleAmphotericin BAntifungal Agentsliposomal amphotericin B

Identifiers

PMID39699427
PMCPMC11654127

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.