Evidence map›Paper›PMID 39699212›Full record

ArticleAntimicrobial agents and chemotherapy2025

Efficacy and safety of praziquantel plus artemisinin-based combinations versus praziquantel in the treatment of Kenyan children with

Charles O Obonyo, Vincent O Were, Peter Wamae, Erick M O Muok

Abstract readEquivalence Trial
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Antischistosomal Ozonide Glycine Ethyl Esters.ACS medicinal chemistry letters · 2026
    Article
  3. Plant-Derived Terpenes as Emerging Therapeutics Against Schistosomiasis.International journal of molecular sciences · 2026
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Charles O ObonyoCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.ORCID 0000-0003-0741-8533
Vincent O WereCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Peter WamaeCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.
Erick M O MuokCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.

Funding

Kenya Medical Research Institute (KEMRI) KEMRI/IRG/012/1
6 · The paper itself

Abstract

Praziquantel alone is insufficient for the control of schistosomiasis due to poor efficacy against juvenile worms and increasing concerns about the risk of drug resistance. We compared the efficacy and safety of praziquantel combined with four different artemisinin-based combinations to praziquantel alone in treating

Indexed as

AnthelminticsArtemisininsPraziquantelSchistosoma mansoniSchistosomiasis mansoniAdolescentAmodiaquineAnimalsArtesunateChildDrug CombinationsDrug Therapy, CombinationFemaleHumansKenyaMaleAmodiaquineAnthelminticsartemisininArtemisininsArtesunateDrug CombinationsMefloquinepiperaquinePiperazinesPraziquantelPyrimethamineQuinolinesSulfadoxineamodiaquineartesunatechildrendihydroartemisininmefloquinepraziquantelschistosomiasissulfalene

Identifiers

PMID39699212
PMCPMC11823657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.