Evidence map›Paper›PMID 39699086›Full record

ReviewComprehensive Physiology2024

Familial Hyperkalemic Hypertension.

Ryan J Cornelius, Yujiro Maeoka, Ujwal Shinde, James A McCormick

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Comprehensive Physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ryan J CorneliusDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Yujiro MaeokaDepartment of Nephrology, Hiroshima University Hospital, Hiroshima, Japan.
Ujwal ShindeDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA.
James A McCormickDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, Oregon, USA.

Funding

Regulation of sodium transport and blood pressure by SPAK/OSR1 kinasesR01DK098141 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI JAMES A MCCORMICK, Ujwal Shinde · 2014 to 2026
$4.2M
Role of the COP9 Signalosome (CSN) in kidney disease and hypertensionK01DK120790 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI CORNELIUS, RYAN J · 2020 to 2024
$650k
The role of the COP9 signalosome in distal nephron remodelingR03DK137034 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI CORNELIUS, RYAN J · 2023 to 2023
$231k
PROP-1 AND PITUITARY DEVELOPMENTF32DK009814 · NIDDK · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI LI, XUE SEAN · 1998 to 2001
$80k
NIDDK NIH HHS F32 DK009814NIDDK NIH HHS K01 DK120790NIDDK NIH HHS R01 DK098141NIDDK NIH HHS R03 DK137034
6 · The paper itself

Abstract

The rare disease Familial Hyperkalemic Hypertension (FHHt) is caused by mutations in the genes encoding Cullin 3 (CUL3), Kelch-Like 3 (KLHL3), and two members of the With-No-Lysine [K] (WNK) kinase family, WNK1 and WNK4. In the kidney, these mutations ultimately cause hyperactivation of NCC along the renal distal convoluted tubule. Hypertension results from increased NaCl retention, and hyperkalemia by impaired K

Indexed as

PseudohypoaldosteronismAdaptor Proteins, Signal TransducingAnimalsCullin ProteinsHumansMicrofilament ProteinsMutationProtein Serine-Threonine KinasesSolute Carrier Family 12, Member 3Adaptor Proteins, Signal TransducingCullin ProteinsKLHL3 protein, humanMicrofilament ProteinsProtein Serine-Threonine KinasesSolute Carrier Family 12, Member 3

Identifiers

PMID39699086
PMCPMC12327360

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.