Evidence map›Paper›PMID 39699020›Full record

ArticleeLife2024

Cytosolic S100A8/A9 promotes Ca

Matteo Napoli, Roland Immler, Ina Rohwedder, Valerio Lupperger, Johannes Pfabe, Mariano Gonzalez Pisfil, Anna Yevtushenko, Thomas Vogl, Johannes Roth, Melanie Salvermoser and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Matteo NapoliWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.ORCID https://orcid.org/0000-0002-8197-9374
Roland ImmlerWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.
Ina RohwedderWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.
Valerio LuppergerInstitute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Johannes PfabeCenter for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Mariano Gonzalez PisfilWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.
Anna YevtushenkoWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.
Thomas VoglInstitute of Immunology, University of Muenster, Muenster, Germany.
Johannes RothInstitute of Immunology, University of Muenster, Muenster, Germany.ORCID https://orcid.org/0000-0001-7035-8348
Melanie SalvermoserWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.
Steffen DietzelWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.
Marjan Slak RupnikCenter for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-3744-4882
Carsten MarrInstitute of AI for Health, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.ORCID https://orcid.org/0000-0003-2154-4552
Barbara WalzogWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.
Markus SperandioWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.ORCID https://orcid.org/0000-0002-7689-3613
Monika PruensterWalter Brendel Center of Experimental Medicine, Biomedical Center, Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University, Planegg-Martinsried, München, Germany.ORCID https://orcid.org/0000-0001-8573-6866

Funding

Deutsche Forschungsgemeinschaft SFB914Deutsche Forschungsgemeinschaft TRR-332Deutsche Forschungsgemeinschaft TRR-359
6 · The paper itself

Abstract

S100A8/A9 is an endogenous alarmin secreted by myeloid cells during many acute and chronic inflammatory disorders. Despite increasing evidence of the proinflammatory effects of extracellular S100A8/A9, little is known about its intracellular function. Here, we show that cytosolic S100A8/A9 is indispensable for neutrophil post-arrest modifications during outside-in signaling under flow conditions in vitro and neutrophil recruitment in vivo, independent of its extracellular functions. Mechanistically, genetic deletion of S100A9 in mice caused dysregulated Ca

Indexed as

CalciumCalgranulin ACalgranulin BLymphocyte Function-Associated Antigen-1Neutrophil InfiltrationNeutrophilsAnimalsCell AdhesionCytosolMiceMice, Inbred C57BLMice, KnockoutCalciumCalgranulin ACalgranulin BLymphocyte Function-Associated Antigen-1S100a8 protein, mouseS100A9 protein, mouseacute inflammationcalcium signalingimmunologyinflammationintracellular S100A8/A9intracellular signalingLFA-1 integrin clusteringmouseneutrophil recruitment

Identifiers

PMID39699020
PMCPMC11658764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.