Evidence map›Paper›PMID 39698979›Full record

ArticleAutophagy2025

Autophagy induction by piplartine ameliorates axonal degeneration caused by mutant HSPB1 and HSPB8 in Charcot-Marie-Tooth type 2 neuropathies.

Angela Sisto, Tamira van Wermeskerken, Michael Pancher, Pamela Gatto, Bob Asselbergh, Ágata Sofia Assunção Carreira, Vicky De Winter, Valentina Adami, Alessandro Provenzani, Vincent Timmerman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Charcot-Marie-Tooth disease and related neuropathies.Nature reviews. Disease primers · 2026
    Review
  3. The Spectrum of Small Heat Shock Protein B8 (International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angela SistoPeripheral Neuropathy Research Group, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-7582-0623
Tamira van WermeskerkenPeripheral Neuropathy Research Group, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Michael PancherHTS Core Facility, University of Trento, Trento, Italy.ORCID 0000-0002-3783-6069
Pamela GattoHTS Core Facility, University of Trento, Trento, Italy.ORCID 0009-0006-7889-1642
Bob AsselberghNeuromics Support Facility, VIB - Center for Molecular Neurology, Antwerp, Belgium.ORCID 0000-0003-2784-2470
Ágata Sofia Assunção CarreiraDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.ORCID 0000-0002-0919-2542
Vicky De WinterPeripheral Neuropathy Research Group, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Valentina AdamiHTS Core Facility, University of Trento, Trento, Italy.ORCID 0000-0002-0617-9393
Alessandro ProvenzaniDepartment of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.ORCID 0000-0003-1652-3415
Vincent TimmermanPeripheral Neuropathy Research Group, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-2162-0933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HSPB1 [heat shock protein family B (small) member 1] and HSPB8 are essential molecular chaperones for neuronal proteostasis, as they prevent protein aggregation. Mutant HSPB1 and HSPB8 primarily harm peripheral neurons, resulting in axonal Charcot-Marie-Tooth neuropathies (CMT2). Macroautophagy/autophagy is a shared mechanism by which HSPB1 and HSPB8 mutations cause neuronal dysfunction. Autophagosome formation is reduced in mutant HSPB1-induced pluripotent stem-cell-derived motor neurons from CMT type 2F patients. Likewise, the HSPB8

Indexed as

AutophagyAxonsChaperoninsCharcot-Marie-Tooth DiseaseHeat-Shock ProteinsHSP27 Heat-Shock ProteinsMolecular ChaperonesMutationAnimalsAutophagosomesDisease Models, AnimalFibroblastsHumansInduced Pluripotent Stem CellsMiceMotor NeuronsChaperoninsHeat-Shock ProteinsHsbp1 protein, mouseHSP27 Heat-Shock ProteinsHSPB1 protein, humanHSPB8 protein, humanHspb8 protein, mouseMolecular ChaperonesAutophagy inducerdrug repurposinginherited peripheral neuropathymotor neuronsphenotypical screeningsmall heat shock proteins

Identifiers

PMID39698979
PMCPMC12013449

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.