SynthesisImmunity, inflammation and disease2024
"Exploring the Link Between Oral Lichen Planus and Xerostomia: A Systematic Literature Review".
Synthesis in Immunity, inflammation and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Adverse Oral Health in Older Adults With Head and Neck Cancer (And Oral Potentially Malignant Disorders): A Systematic Review.Gerodontology · 2026Pooled it
- Effects of Probiotics and Vitamin D Deficiency Correction on Clinical, Inflammatory, Metabolic, and Microbiota Profiles in Older Adults with Oral Lichen Planus: A Multi-Omics Study.International journal of molecular sciences · 2026Article
- Assessment of Anti-M3R antibody in patients with oral lichen planus complaining of xerostomia: a preliminary study.BMC oral health · 2026Article
- Circulating Antibodies Against DSG1 and DSG3 in Patients with Oral Lichen Planus: A Scoping Review.Antibodies (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
introductionOral lichen planus (OLP) is a chronic disorder affecting the oral mucosa, potentially associated with xerostomia, either independently or concurrently. Research suggests that approximately 45% of patients with erythematous and ulcerative OLP may experience dry mouth sensations. The aim of this systematic review is to assess the current literature regarding the potential relationship or co-occurrence of xerostomia with OLP. Understanding this association is imperative for the development of comprehensive management strategies and the improvement of patient outcomes. METHOD AND MATERIAL: The study followed the PRISMA 2020 checklist and included human studies, specifically investigating xerostomia in patients with OLP. After screening 897 articles, 9 studies were selected based on predefined criteria Quality assessment was conducted using the Cochrane risk of bias tools: ROB 2 for RCTs and ROBINS-I for non-randomized studies Scale was conducted to evaluate potential biases in study design, selection, and outcomes.
resultA systematic review of nine studies (1960-2023) examining xerostomia in OLP patients found a significant reduction in unstimulated salivary flow rates in many cases. Although evidence links xerostomia with OLP, a definitive causal relationship remains unestablished. Some studies highlighted Candida infection, altered saliva protein expression, and inflammation-related nerve damage as contributing factors to dry mouth in OLP patients. DISCUSSION AND
conclusionThis systematic review examines the potential relationship between OLP and xerostomia, focusing on factors such as salivary flow, histopathological changes, and immune-related mechanisms. While some studies suggest a link between OLP and reduced saliva production, no definitive causal relationship has been established. The review identified significant research gaps, including inconsistent methodologies and a lack of standardized criteria. Future studies should explore different OLP forms, receptor interactions, immune responses, and neuropeptides to gain a better understanding of xerostomia's etiopathogenesis and improve management strategies for OLP patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.