Evidence map›Paper›PMID 39698930›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2024

Neddylation drives myofibrillogenesis in the developing heart.

Rodney Littlejohn, Josue Zambrano-Carrasco, Jianqiu Zou, Yi Lu, Elise Liu, Il-Man Kim, Kai Jiao, Neal L Weintraub, Jiliang Zhou, Jie Li and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rodney LittlejohnVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0009-0004-6196-5858
Josue Zambrano-CarrascoVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0003-4802-8443
Jianqiu ZouVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0003-4199-9212
Yi LuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-3187-8487
Elise LiuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0009-0004-5140-4475
Il-Man KimVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-9268-8337
Kai JiaoCenter for Biotechnology & Genomic Medicine, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-5415-9020
Neal L WeintraubVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-5138-3705
Jiliang ZhouDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-2375-4636
Jie LiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0003-3902-642X
Huabo SuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-8475-2685

Funding

Neddylation and cardiac protein quality controlR01HL124248 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2014 to 2024
$4.1M
Wrestling stress: role of ufm1 modification in pathological cardiac remodelingR01HL146807 · NHLBI · AUGUSTA UNIVERSITY · PI Jie Li · 2020 to 2026
$2.7M
Mitochondrial quality control in the heartR01HL165205 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2022 to 2025
$2.4M
Elucidating the role of Cullin 3 in the heartR01HL173796 · NHLBI · AUGUSTA UNIVERSITY · PI Huabo Su · 2024 to 2026
$2.0M
Identifying novel pathways targeting endothelial-to-mesenchymal transition during heart failureR01HL146481 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI KIM, IL-MAN · 2019 to 2022
$1.6M
SPECIFIC ENRICHMENT OF MYOGLOBINS FOR CARBON-13 NMRR01HL014680 · NHLBI · INDIANA UNIVERSITY BLOOMINGTON · PI GURD, FRANK R · 1985 to 1985
–
American Heart Association (AHA) 17CPRE33650056American Heart Association (AHA) 23PRE1012641HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL124248HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL146807A1HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL165205NHLBI NIH HHS R01 HL124248NHLBI NIH HHS R01 HL146481NHLBI NIH HHS R01 HL146807NHLBI NIH HHS R01 HL165205NHLBI NIH HHS R01 HL173796
6 · The paper itself

Abstract

Neddylation is a highly conserved post-translational modification that plays critical roles in various cellular processes through the modulation of cullins and non-cullin substrates. While neddylation is known to be essential for embryonic development, tumor growth, and organogenesis of different tissues, its role in cardiogenesis remains unexplored. Here, we investigated the role of neddylation in early cardiac development by deleting the gene encoding a regulatory subunit of the NEDD8-specific E1 activating enzyme, Nae1, globally and in a heart-specific fashion via Nkx2-5

Indexed as

HeartMice, KnockoutNEDD8 ProteinAnimalsCell ProliferationFemaleGene Expression Regulation, DevelopmentalMiceMyocardiumMyocytes, CardiacMyofibrilsOrganogenesisProtein Processing, Post-TranslationalUbiquitin-Activating EnzymesNEDD8 ProteinNedd8 protein, mouseUbiquitin-Activating Enzymescardiac developmentmyofibril assemblyNAE1Neddylation

Identifiers

PMID39698930
PMCPMC11694678

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.