Evidence map›Paper›PMID 39698882›Full record

ArticleCurrent pharmaceutical design2025

Metabolomics and Anticancer Potential of the Aerial Parts of

Khalil Said, Mamoona Rauf, Sumera Afzal Khan, Anwar Hussain, Alaa S Alhegaili, Sajid Hussain, Sajid Ali, Muhammad Hamayun

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Article in Current pharmaceutical design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Khalil SaidDepartment of Botany, Abdul Wali Khan University Mardan, Garden Campus, Mardan, Pakistan.
Mamoona RaufDepartment of Botany, Abdul Wali Khan University Mardan, Garden Campus, Mardan, Pakistan.
Sumera Afzal KhanCenter of Biotechnology and Microbiology, University of Peshawar, Peshawar, Pakistan.
Anwar HussainDepartment of Botany, Abdul Wali Khan University Mardan, Garden Campus, Mardan, Pakistan.
Alaa S AlhegailiDepartment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia.
Sajid HussainDepartment of Pharmacy, Kohat University of Science and Technology, Kohat, Pakistan.
Sajid AliDepartment of Horticulture and Life Science, Yeungnam University, Gyeongsan, Republic of Korea.
Muhammad HamayunDepartment of Botany, Abdul Wali Khan University Mardan, Garden Campus, Mardan, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction

aimThe present study aimed to elucidate the plant's medicinal potential as an anticancer agent. Extracts of

methodsThree different cell lines have been treated against Ethanol, Methanol, Ethyl acetate, Water, Chloroform, Acetone, and n-hexane extracts from the aerial parts of

resultsExtracts showed a significant effect in different cell lines (based on IC50 less than 200 ug/ml). Performing the

conclusionFor multi-scale frames structural aberrations and fluctuations identification of the docked complexes, a molecular dynamics analysis was performed for a 100 ps simulation run by accessing the online tool of MDweb simulations. These molecular docking and simulation analyses also revealed that both the phytochemicals have a stable interaction with the cancer-related proteins BCL2 and 5P21.

Indexed as

Antineoplastic Agents, PhytogenicDryopterisMetabolomicsPlant Components, AerialPlant ExtractsCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansAntineoplastic Agents, PhytogenicPlant Extractsanticancer potentialcomputational approachesDryopteris ramosaGC-ToF-MS analysismolecular docking and simulationpesticides.

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.