Evidence map›Paper›PMID 39698793›Full record

ArticleJournal of dental research2025

Multiancestry Genome-Wide Association Study of Early Childhood Caries.

P Shrestha, M Graff, Y Gu, Y Wang, C L Avery, J Ginnis, M A Simancas-Pallares, A G Ferreira Zandoná, R N Alotaibi, E Orlova and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Genomic basis of developmental defects of enamel and sex-specific effects.medRxiv : the preprint server for health sciences · 2026
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

P ShresthaDepartment of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.ORCID 0000-0002-1604-082X
M GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
Y GuDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
Y WangDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
C L AveryDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
J GinnisDepartment of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.
M A Simancas-PallaresDepartment of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.
A G Ferreira ZandonáDepartment of Comprehensive Care, School of Dental Medicine, Tufts University, Boston, MA, USA.
R N AlotaibiDental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
E OrlovaCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine; Department of Human Genetics, School of Public Health; University of Pittsburgh, Pittsburgh, PA, USA.
H S AhnDepartment of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.
K N NguyenDepartment of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.
H M HighlandDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
D Y LinDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
J S PreisserDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
G D SladeDepartment of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.
M L MarazitaCenter for Craniofacial and Dental Genetics, Department of Oral and Craniofacial Sciences, School of Dental Medicine; Department of Human Genetics, School of Public Health; University of Pittsburgh, Pittsburgh, PA, USA.
K E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, NC, USA.
K DivarisDepartment of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, NC, USA.ORCID 0000-0003-1290-7251

Funding

Genome-Wide Association Study of Early Childhood CariesU01DE025046 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DIVARIS, KIMON · 2015 to 2019
$8.4M
NIDCR NIH HHS U01 DE025046
6 · The paper itself

Abstract

Early childhood caries (ECC) is the most common noncommunicable childhood disease-an important health problem with known environmental and social/behavioral influences lacking consensus genetic risk loci. To address this knowledge gap, we conducted a genome-wide association study of ECC in a multiancestry population of U.S. preschool-age children (

Indexed as

Dental CariesGenome-Wide Association StudyChild, PreschoolDMF IndexFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansMalePhenotypeUnited Statesdental cariesgene-environment interactiongeneticsgenetic variantsgenomicsheritabilitysingle nucleotide polymorphism

Identifiers

PMID39698793
PMCPMC11843792

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.