Observational studyJournal of diabetes investigation2025
Rising mortality rates linked to type-2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022.
Observational study in Journal of diabetes investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Once-Weekly Insulin Efsitora Alfa Versus Once Daily Insulin in Patients With Type 2 Diabetes: A Systematic Review and Meta-Analysis.Endocrinology, diabetes & metabolism · 2025Pooled it
- Cardiometabolic health of low- and higher-income adults in the United States, 2009-2023.American heart journal · 2026Article
- Temporal patterns in diabetes and sepsis mortality in older Americans: a population-based analysis.BMC geriatrics · 2026Article
- Temporal trends and projections in Hypertension with Substance Use-related mortality, 1999-2035: Insights from the CDC WONDER database.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Race, ethnicity and ancestry in global diabetes research: grappling with complexity to advance equity and scientific integrity - a narrative review and viewpoint.Diabetologia · 2025Review
- Regional and demographic variations in diabetes mellitus and myocardial infarction mortality among US adults: A retrospective observational analysis from 1999 to 2023.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Concomitant mortality trends due to obesity and hypertension in the U.S.: a 20-year retrospective analysis of the CDC WONDER database.BMC cardiovascular disorders · 2025Article
- Trends and Disparities in Hemorrhagic Stroke and Hypertension-Related Mortality in the United States From 1999 to 2023: A CDC WONDER Database Analysis.Brain and behavior · 2025Article
- The Interplay of Cancer and Hypertension: Rising Mortality and Widening Disparities Across the United States (1999-2023).Medicina (Kaunas, Lithuania) · 2025Observational
- Author's Reply to Letter to Editor in response to the article "Rising mortality rates linked to type-2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022".Journal of diabetes investigation · 2025Article
- Rising Mortality Related to Diabetes Mellitus and Hypertension: Trends and Disparities in the United States (1999-2023).Clinical cardiology · 2025Article
- Letter to Editor in response to the article "Rising mortality rates linked to type-2 diabetes and obesity in the United States: An observational analysis from 1999 to 2022".Journal of diabetes investigation · 2025Article
- Does abnormal weight affect sperm quality? A case-control study based on bioelectrical impedance analysis.Frontiers in nutrition · 2025Article
- Changing trends in myocardial infarction mortality among young adults in the United States: a 25-year analysis of disparities and the COVID-19 impact.Archives of medical sciences. Atherosclerotic diseases · 2025Article
- Global, regional, and national burden of knee osteoarthritis attributable to high BMI: a systematic analysis from 1990 to 2021 and projections to 2050.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of type 2 diabetes (T2D) and obesity are increasing in the United States. However, population-level data for mortality trends due to T2D and obesity are limited. This study aims to assess these death trends among adults in the United States categorized by sex, race, and geographical location.
methodsWe queried the CDC-WONDER database for multiple cause of death data of adults aged ≥25 years. The crude mortality rates (CMR), age-adjusted mortality rates (AAMRs), annual percent change (APC), and the average APC (AAPC) along with a 95% confidence interval (CI) were analyzed.
resultsFrom 1999 to 2022, a total of 88,597 T2DM and obesity-related deaths were recorded in the United States. The AAMR consistently increased from 1999 to 2017 (APC: 7.64; 95% CI: 1.91-9.96), followed by a marked rise from 2017 to 2022 (APC: 20.13; 95% CI: 12.88-38.57). The AAMR was approximately 3.58 times higher during the COVID-19 pandemic compared to the period from 1999 to 2019. The AAMR for males was consistently greater than that for females. The highest AAMR was observed in non-Hispanic (NH) Blacks or African Americans, followed by NH White, Hispanic or Latino, and other NH populations. Rural areas (AAMR: 1.86, 95% CI: 1.83-1.89) exhibited a greater AAMR than urban regions 1.26 (95% CI: 1.25-1.27).
conclusionsOur results indicate a substantial increasing trend of T2D and obesity-related deaths in the United States especially during the COVID-19 pandemic.
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