ArticleQuantitative imaging in medicine and surgery2024
Article in Quantitative imaging in medicine and surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Research hotspots and trends of pediatric bone age: A bibliometric and visualization analysis.Lasers in medical science · 2025Article
- Role of vitamins in the development and treatment of osteoporosis (Review).International journal of molecular medicine · 2025Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Quantitative assessment of cortical bone microstructure is crucial for the evaluation of osteoporosis, yet current clinical methods such as dual-energy X-ray absorptiometry (DXA) have many limitations. The Methods: Healthy volunteers without osteoporosis risk factors were enrolled and underwent double-echo UTE MRI of the proximal femur. Porosity index (PI) and cortical bone thickness (CbTh) were obtained manually by two radiologists independently on double-echo UTE images using image processing software. Repeatability of PI and CbTh measurements were evaluated using intra-class correlation coefficient (ICC) analysis. PI and CbTh of different limbs and sexes were compared, and P<0.05 indicated statistical significance for these analyses. Correlations of PI and CbTh with age and body mass index (BMI) were assessed by Pearson or Spearman correlation coefficient as well as the partial Pearson correlation coefficient. Curve estimation was used to assess non-monotonic variable correlations in scatterplots. For these analyses, P<0.025 indicated statistical significance according to the Bonferroni correction. Results: A total of 52 healthy cases (33 males, 19 females) aged 22-55 years were included for analysis, where no statistical difference in age was found between sexes (P=0.586) and BMI of males was greater than that of females (P=0.007). The repeatability of PI and CbTh measurements was excellent (ICC 0.985 and 0.943, respectively). The proximal femoral cortical PI was greater on the non-dominant side (P<0.001). PI was greater in males than in females (non-dominant: P<0.001, dominant: P=0.032) and CbTh was greater on the non-dominant side in males than in females (P=0.036) after excluding the effect of confounding factor (BMI). PI on the dominant side was positively correlated with BMI in males (r=0.535, P=0.001), and CbTh on the non-dominant side was positively correlated with BMI in males (r=0.482, P=0.005). There was a U-shaped curve trend between dominant side cortical PI and age in females (y = 65.32 - 1.88x + 0.02x Conclusions: Double-echo UTE MRI enables
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